Distinct differences in striatal dysmorphology between attention deficit hyperactivity disorder boys with and without a comorbid reading disability.
Distinct differences in striatal dysmorphology between attention deficit hyperactivity disorder boys with and without a comorbid reading disability.
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DOI：
10.1016/j.pscychresns.2016.10.012
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发表时间：
2016-12-30
期刊：
影响因子：
--
通讯作者：
Stanley JA
中科院分区：
文献类型：
--
作者：
Goradia DD;Vogel S;Mohl B;Khatib D;Zajac-Benitez C;Rajan U;Robin A;Rosenberg DR;Stanley JA
有证据表明，与单独的 ADHD（ADHD/−RD）相比，伴有阅读障碍的注意力缺陷多动障碍（ADHD/+RD）的认知缺陷更大。此外，纹状体一直与多动症有关。然而，人们对 ADHD/+RD 纹状体形态改变的程度知之甚少，而这正是本研究的主要目的。根据结构 MRI 图像，对 59 名年龄和智商相匹配的男孩的尾状核和壳核表面变形进行了评估 [19 名 ADHD/−RD、15 名 ADHD/+RD 和 25 名典型发育对照 (TDC)]。进行基于顶点的多重比较校正分析，以将 ADHD/-RD 和 ADHD/+RD 与 TDC 进行比较。与 TDC 相比，ADHD/+RD 显示出多个双侧显着的表面压缩簇。相比之下，ADHD/−RD 显示出较少的明显表面压缩簇，并且仅限于左侧。对于壳核，只有 ADHD/−RD 显示出明显的表面压缩簇。结果首次证明，与 TDC 相比，ADHD/+RD 尾状核的形态学改变程度更大，这可能表明投射到尾状核的皮层区域更大，与 ADHD/+RD 中观察到的更大的神经心理损伤相关。
There is evidence of greater cognitive deficits in attention deficit hyperactivity disorder with a comorbid reading disability (ADHD/+RD) compared to ADHD alone (ADHD/−RD). Additionally, the striatum has been consistently implicated in ADHD. However, the extent of morphological alterations in the striatum of ADHD/+RD is poorly understood, which is the main purpose of this study. Based on structural MRI images, the surface deformation of the caudate and putamen was assessed in 59 boys matching in age and IQ [19 ADHD/−RD, 15 ADHD/+RD and 25 typically developing controls (TDC)]. A vertex based analysis with multiple comparison correction was conducted to compare ADHD/−RD and ADHD/+RD to TDC. Compared to TDC, ADHD/+RD showed multiple bilateral significant clusters of surface compression. In contrast, ADHD/−RD showed fewer significant clusters of surface compression and restricted to the left side. Regarding the putamen, only ADHD/−RD showed significant clusters of surface compression. Results demonstrate for the first time a greater extent of morphological alterations in the caudate of ADHD/+RD than ADHD/−RD compared to TDC, which may suggest greater implicated cortical areas projecting to the caudate that are associated with the greater neuropsychological impairments observed in ADHD/+RD.
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