Synaptophysin expression in rat retina following acute high intraocular pressure.
Synaptophysin expression in rat retina following acute high intraocular pressure.
复制标题
急性高眼压后大鼠视网膜中突触素的表达。
DOI：
10.1267/ahc.08034
复制
发表时间：
2008-12-27
影响因子：
2.4
通讯作者：
Xue-Gang L
中科院分区：
文献类型：
--
作者：
Dan C;Jian-Bin T;Hui W;Le-Ping Z;Jin Z;Ju-Fang H;Xue-Gang L
作为对损伤的响应，突触改变可能比神经元细胞体的变化更早发生。虽然在急性高眼压（HIOP）后发现视网膜神经节细胞死亡和视网膜内部变薄，但视网膜中突触的结构和功能变化仍不清楚。本研究探讨了突触素（synaptophysin，SYN）的蛋白和mRNA表达，SYN是与突触活动、突触发生和突触可塑性密切相关的重要分子。此外，我们还研究了视网膜突触的超微结构变化。结果发现：（1）HIOP后突触体素在蛋白和mRNA水平均短暂上调;（2）HIOP早期外核层内突触体素蛋白分布增宽;（3）电镜观察到外核层内存在含囊泡的扣合样结构。这些数据表明，除了变性，大鼠视网膜中的突触可能经历再生事件后HIOP。
In response to injury, synapse alteration may occur earlier than the changes in the cell body of neurons. Although retinal ganglion cell death and thinning of the inner part of retina were found after acute high intraocular pressure (HIOP), the structural and functional changes of synapses in the retina remain unknown. In the present study, we investigated the protein and mRNA expression of synaptophysin (SYN), an important molecule closely related to synaptic activities, synaptogenesis and synaptic plasticity. In addition, we also studied the ultrastructural changes of the retinal synapses. We found that (1) synaptophysin was upregulated transiently at both protein and mRNA level following HIOP; (2) broadened distribution of synaptophysin protein was present within the outer nuclear layer at the early stage following HIOP; (3) in the outer nuclear layer bouton-like vesicle-containing structures were observed by electron microscopy. This data suggested that, besides degeneration, synapses in rat retina may undergo regenerative events following HIOP.
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影响因子：
4.7
作者：
Singh, M;Savitz, SI;Rosenbaum, DM
通讯作者：
Rosenbaum, DM
影响因子：
2.9
作者：
Nag, TC;Wadhwa, S
通讯作者：
Wadhwa, S
影响因子：
--
作者：
Yücel, YH;Gupta, N;Weinreb, RN
通讯作者：
Weinreb, RN
DOI：
10.1007/bf02539411
发表时间：
1996-07-01
影响因子：
2.7
作者：
Adachi, M;Takahashi, K;Uyama, M
通讯作者：
Uyama, M
影响因子：
1.7
作者：
Cheon, EW;Park, CH;Choi, WS
通讯作者：
Choi, WS