Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.
Cutting edge: attrition of Plasmodium-specific memory CD8 T cells results in decreased protection that is rescued by booster immunization.
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DOI：
10.4049/jimmunol.1003949
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发表时间：
2011-04-01
期刊：
影响因子：
--
通讯作者：
Harty JT
中科院分区：
文献类型：
--
作者：
Schmidt NW;Harty JT
对疟原虫孢子虫感染的无菌保护需要大量的记忆性CD8 t细胞。然而，不相关病原体的感染，如可能发生在疟疾流行地区，会显著减少预先存在的记忆性CD8 t细胞。目前尚不清楚不相关的感染是否会损害疟原虫特异性记忆CD8 t细胞的数量，从而限制亚单位疫苗接种产生的抗疟疾免疫的持续时间。我们发现伯氏假单胞菌环孢子体特异性记忆CD8 t细胞在受到无关感染的小鼠中经历了显著的数量损耗。磨损与效应记忆CD8 t细胞的优先丧失和对伯氏假体孢子虫攻击的免疫力降低有关。然而，与在疟疾流行地区部署疟原虫疫苗相关的是，记忆性CD8 t细胞的损耗可通过加强免疫逆转，从而恢复保护作用。这些数据表明，在面对由无关感染引起的损耗时，可能需要定期加强免疫以维持疫苗诱导的保护性疟原虫特异性记忆CD8 t细胞。
Sterile protection against infection with Plasmodium sporozoites requires high numbers of memory CD8 T-cells. However, infections with unrelated pathogens, as may occur in malaria endemic areas, dramatically decrease pre-existing memory CD8 T-cells. It remains unknown whether unrelated infections will compromise numbers of Plasmodium-specific memory CD8 T-cells and thus limit the duration of anti-malarial immunity generated by subunit vaccination. We show that P. berghei circumsporozoite-specific memory CD8 T-cells underwent significant attrition in numbers in mice subjected to unrelated infections. Attrition was associated with preferential loss of effector memory CD8 T-cells and reduced immunity to P. berghei sporozoite challenge. However, and of relevance to deployment of Plasmodium vaccines in malaria endemic areas, attrition of memory CD8 T-cells was reversed by booster immunization, which restored protection. These data suggest that regular booster immunizations may be required to sustain protective vaccine-induced Plasmodium-specific memory CD8 T-cells in the face of attrition caused by unrelated infections.
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影响因子：
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