Top-down and bottom-up approaches in production of aqueous nanocolloids of low solubility drug paclitaxel.
Top-down and bottom-up approaches in production of aqueous nanocolloids of low solubility drug paclitaxel.
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DOI：
10.1039/c0cp02549f
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发表时间：
2011-05-21
期刊：
影响因子：
--
通讯作者：
Lvov Y
中科院分区：
文献类型：
--
作者：
Pattekari P;Zheng Z;Zhang X;Levchenko T;Torchilin V;Lvov Y
采用超声辅助层层包覆法制备难溶性抗癌药物的纳米胶囊。我们改变了LBL封装的策略，从在壁中具有许多层以封装高度可溶性材料的微胶囊到在低可溶性纳米颗粒上使用非常薄的聚阳离子/聚阴离子涂层以提供其良好的胶体稳定性。紫杉醇的SLbL包封产生稳定的100-200 nm直径的胶体，其具有高的电表面电位（-45 mV）和90重量%的纳米颗粒中的药物含量。在自上而下的方法中，通过使用超声破碎紫杉醇粉末并同时顺序吸附带相反电荷的生物相容性聚电解质来制备纳米胶体。在自下而上的方法中，将紫杉醇溶解在有机溶剂（乙醇或丙酮）中，并且通过在超声处理辅助下加入含水的水溶液来逐渐恶化溶液来引发药物成核。通过组装具有可变厚度的多层壳来控制来自这种纳米胶囊的紫杉醇释放速率，并且在10-20小时的范围内。
Nano-encapsulation of poorly soluble anticancer drug was developed with sonication assisted layer-by-layer polyelectrolyte coating (SLbL). We changed the strategy of LbL-encapsulation from making microcapsules with many layers in the walls for encasing highly soluble materials to using very thin polycation / polyanion coating on low soluble nanoparticles to provide their good colloidal stability. SLbL encapsulation of paclitaxel resulted in stable 100-200 nm diameter colloids with high electrical surface ξ-potential (of -45 mV) and drug content in the nanoparticles of 90 wt %. In the top-down approach, nanocolloids were prepared by rupturing powder of paclitaxel using ultrasonication and simultaneous sequential adsorption of oppositely charged biocompatible polyelectrolytes. In the bottom-up approach paclitaxel was dissolved in organic solvent (ethanol or acetone), and drug nucleation was initiated by gradual worsening the solution with the addition of aqueous polyelectrolyte assisted by ultrasonication. Paclitaxel release rates from such nanocapsules were controlled by assembling multilayer shells with variable thicknesses and are in the range of 10-20 hours.
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影响因子：
3.9
作者：
Szczepanowicz, K.;Hoel, H. J.;Warszynski, P.
通讯作者：
Warszynski, P.
影响因子：
3.9
作者：
Cheng, Yue-an;Zheng, Bin;Hsieh, Shuchen
通讯作者：
Hsieh, Shuchen
影响因子：
7.3
作者：
Fernandez, AM;Van Derpoorten, K;Trouet, A
通讯作者：
Trouet, A
影响因子：
3.3
作者：
Antipov, AA;Sukhorukov, GB;Möhwald, H
通讯作者：
Möhwald, H
DOI：
10.1073/pnas.92.15.6920
发表时间：
1995-07-18
影响因子：
11.1
作者：
MASTROPAOLO, D;CAMERMAN, A;CAMERMAN, N
通讯作者：
CAMERMAN, N