CDK5 serves as a major control point in neurotransmitter release.-猫眼课题宝

DOI：

10.1016/j.neuron.2010.08.003

发表时间：

2010-09-09

期刊：

NEURON

影响因子：

16.2

通讯作者：

中科院分区：

医学1区

文献类型：

作者：

Kim, Sung Hyun;Ryan, Timothy A.

来源链接：

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939042/?report=classic

CDK5是神经系统功能中的重要激酶，控制神经发育和突触后信号整合，我们表明CDK5在控制CDK5的抑制中起着主要作用。包括先前“静音”突触的删除CDK5活性。与CDK5 KD相似的治疗方法在突触前的情况下，CDK5似乎是突触前稳态缩放的组成部分，而静止的场地池似乎提供了潜在的功能性官能稳态控制参数。在哺乳动物神经元中调节神经递质释放的主要控制点。

CDK5 is an important kinase in nervous system function, controlling neural development and postsynaptic signal integration. Here we show that CDK5 plays a major role in controlling neurotransmitter release. Inhibition of CDK5 activity, by either acute or genetic means leads to profound potentiation of presynaptic function, including unmasking of previously “silent” synapses. Removal of CDK5 activity additionally unlocks access to the resting synaptic vesicle pool, which normally remains recalcitrant to exocytosis and recycling even following prolonged action potential stimuli. Presynaptic CDK5 levels are additionally severely depleted by chronic neuronal silencing, a treatment that is functionally similar to CDK5 KD with regard to presynaptic potentiation. Thus CDK5 appears to be an integral element in presynaptic homeostatic scaling and the resting vesicle pool appears to provide a potent functional presynaptic homeostatic control parameter. These studies thus pinpoint CDK5 as a major control point for modulation of neurotransmitter release in mammalian neurons.