Presbycusis phenotypes form a heterogeneous continuum when ordered by degree and configuration of hearing loss.
Presbycusis phenotypes form a heterogeneous continuum when ordered by degree and configuration of hearing loss.
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DOI：
10.1016/j.heares.2010.02.001
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发表时间：
2010-06-01
期刊：
影响因子：
2.8
通讯作者：
Eddins, David A.
中科院分区：
文献类型：
--
作者：
Allen, Paul D.;Eddins, David A.
许多报告记录了不同人群的平均听阈值随着年龄的增加而增加的情况。尽管如此，不同形式的听力损失在老年性耳聋中的流行率仍然不确定。我们在960名受试者(552名女性，408名男性，18岁到92岁)的数据库中检查了老年性耳聋的表型，每个受试者都有30个外周听力敏感度指标：左耳和右耳的纯音测听图，从0.25 kHz到8 kHz，每只耳的DPOAE，F均值=1到6.4 kHz。令人惊讶的是，听力表型并没有自然地分为不同的老年性耳聋类别。主成分(PC)分析表明，在30项听力指标中，两个主成分可以解释74%的方差。这两个分量代表损失的总体程度(PC1)和形态(平坦与倾斜；PC2)，当与它们相对照时，表型形成一个连续体。对这一连续体的启发式划分产生了不同程度的倾斜性或平坦性听力损失的老年性耳聋，这表明先前报道的老年性耳聋的亚型来自连续和不同分布的分类隔离。此外，大多数表型位于平坦或倾斜损失的极端中间，这表明如果测听配置确实可以预测老年性耳聋的病因，那么混合来源是最普遍的。
Many reports have documented age-by-frequency increases in average auditory thresholds in various human populations. Despite this, the prevalence of different patterns of hearing loss in presbycusis remains uncertain. We examined presbycusis phenotypes in a database of 960 subjects (552 female, 408 male, 18 to 92 yrs) that each had 30 measures of peripheral hearing sensitivity: pure tone audiograms for left and right ears from 0.25 kHz to 8 kHz and DPOAE for each ear with Fmean = 1 to 6.4 kHz. Surprisingly, the hearing phenotypes did not naturally separate into discrete classes of presbycusis. Principal component (PC) analysis revealed that two principal components account for 74 % of the variance among the 30 measures of hearing. The two components represent the overall degree (PC1) and configuration of loss (Flat vs. Sloping; PC2) and the phenotypes form a continuum when plotted against them. A heuristic partitioning of this continuum produced classes of presbycusis that vary in their degree of Sloping or Flat hearing loss, suggesting that the previously reported sub-types of presbycusis arise from the categorical segregation of a continuous and heterogeneous distribution. Further, most phenotypes lie intermediate to the extremes of either Flat or Sloping loss, indicating that if audiometric configuration does predict presbycusis etiology, then a mixed origin is the most prevalent.
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影响因子：
2.4
作者：
Divenyi, PL;Stark, PB;Haupt, KM
通讯作者：
Haupt, KM
影响因子：
5.3
作者：
Kujawa, SG;Liberman, MC
通讯作者：
Liberman, MC
影响因子：
2.9
作者：
Ohlemiller, Kevin K.
通讯作者：
Ohlemiller, Kevin K.
影响因子：
3.7
作者：
Humes, LE
通讯作者：
Humes, LE
DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kujawa SG;Liberman MC
通讯作者：
Liberman MC