Association among serum perfluoroalkyl chemicals, glucose homeostasis, and metabolic syndrome in adolescents and adults.
Association among serum perfluoroalkyl chemicals, glucose homeostasis, and metabolic syndrome in adolescents and adults.
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DOI：
10.2337/dc08-1816
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发表时间：
2009-04
期刊：
影响因子：
16.2
通讯作者：
Lin LY
中科院分区：
文献类型：
--
作者：
Lin CY;Chen PC;Lin YC;Lin LY
全氟烷基化学品（PFCs）已在全球范围内用于各种消费品。PFCs对葡萄糖稳态的影响尚不清楚。我们从1999-2000年和2003-2004年国家健康和营养检查调查中检测了474名青少年和969名成年人代谢综合征的可靠血清指标。在青少年中，血清全氟壬酸（PFNA）浓度升高与高血糖相关（比值比[OR] 3.16 [95% CI 1.39-7.16]，P < 0.05）。血清PFNA浓度升高与血清HDL胆固醇水平呈正相关（0.67 [0.45-0.99]，P < 0.05）。总体而言，血清PFNA浓度升高与代谢综合征的患病率呈负相关（0.37 [0.21-0.64]，P < 0.005）。在成人中，血清全氟辛酸浓度升高与β细胞功能增强显著相关（β系数0.07 ± 0.03，P < 0.05）。血清全氟辛烷磺酸（PFOS）浓度升高与血胰岛素（0.14 ± 0.05，P < 0.01）、稳态模型评估的胰岛素抵抗（0.14 ± 0.05，P < 0.01）和β细胞功能（0.15 ± 0.05，P < 0.01）升高相关。血清全氟辛烷磺酸浓度也与血清高密度脂蛋白胆固醇呈不利相关（OR 1.61 [95% CI 1.15-2.26]，P < 0.05）。血清PFCs与血糖稳态和代谢综合征指标相关。进一步的临床和动物研究是必要的，以澄清推定的因果关系。
Perfluoroalkyl chemicals (PFCs) have been used worldwide in a variety of consumer products. The effect of PFCs on glucose homeostasis is not known. We examined 474 adolescents and 969 adults with reliable serum measures of metabolic syndrome profile from the National Health and Nutrition Examination Survey 1999–2000 and 2003–2004. In adolescents, increased serum perfluorononanoic acid (PFNA) concentrations were associated with hyperglycemia (odds ratio [OR] 3.16 [95% CI 1.39–7.16], P < 0.05). Increased serum PFNA concentrations also have favorable associations with serum HDL cholesterol (0.67 [0.45–0.99], P < 0.05). Overall, increased serum PFNA concentrations were inversely correlated with the prevalence of the metabolic syndrome (0.37 [0.21–0.64], P < 0.005). In adults, increased serum perfluorooctanoic acid concentrations were significantly associated with increased β-cell function (β coefficient 0.07 ± 0.03, P < 0.05). Increased serum perfluorooctane sulfate (PFOS) concentrations were associated with increased blood insulin (0.14 ± 0.05, P < 0.01), homeostasis model assessment of insulin resistance (0.14 ± 0.05, P < 0.01), and β-cell function (0.15 ± 0.05, P < 0.01). Serum PFOS concentrations were also unfavorably correlated with serum HDL cholesterol (OR 1.61 [95% CI 1.15–2.26], P < 0.05). Serum PFCs were associated with glucose homeostasis and indicators of metabolic syndrome. Further clinical and animal studies are warranted to clarify putative causal relationships.
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影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
7.4
作者：
Kuklenyik, Z;Needham, LL;Calafat, AM
通讯作者：
Calafat, AM
影响因子：
4.9
作者：
Alexander, BH;Olsen, GW;Mandel, JS
通讯作者：
Mandel, JS
影响因子：
3.8
作者：
Butenhoff, J;Costa, G;Thomford, P
通讯作者：
Thomford, P
影响因子：
8
作者：
Li, Chaoyang;Ford, Earl S.;Cook, Stephen
通讯作者：
Cook, Stephen