Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern.
Recirculating memory T cells are a unique subset of CD4+ T cells with a distinct phenotype and migratory pattern.
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DOI：
10.4049/jimmunol.1202805
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发表时间：
2013-02-01
期刊：
影响因子：
--
通讯作者：
Luster AD
中科院分区：
文献类型：
--
作者：
Bromley SK;Yan S;Tomura M;Kanagawa O;Luster AD
记忆T细胞的几个种群在迁移和功能上有所不同。在这里，我们已经确定了记忆T细胞的一个独特子集，我们将其命名为循环记忆T细胞（TRCM）。通过将Kaede转基因小鼠皮肤暴露在紫光下，我们追踪了皮肤T细胞的命运。一群记忆性CD4+ T细胞留在skiñA中，另一群细胞以ccr7依赖的方式从皮肤迁移到引流淋巴结（LNs）。这些迁移的CD4+ T细胞表达了一种新的细胞表面表型（CCR7int/+ CD62Lint CD69−CD103+/−e -选择素配体+），不同于迄今为止描述的记忆T细胞亚群。与记忆T细胞亚群长期驻留在组织内，或仅在淋巴组织之间迁移或迁移到外周非淋巴组织不同，CD4+ TRCM从皮肤迁移到引流LNs。它们从引流LN重新进入循环、远端LN和非特异性皮肤炎症部位。此外，在多克隆刺激后，CD4+ TRCM上调CD40L并分泌IL-2。总之，我们的研究结果确定了一种新的循环记忆CD4+ T细胞亚群，它们能够为远端淋巴组织和皮肤组织提供帮助。
Several populations of memory T cells have been described that differ in their migration and function. Here, we have identified a unique subset of memory T cells, which we have named recirculating memory T cells (TRCM). By exposing Kaede transgenic mouse skin to violet light, we tracked the fate of cutaneous T cells. One population of memory CD4+ T cells remained in the skiñA second population migrated from the skin into draining lymph nodes (LNs) in a CCR7-dependent manner. These migrating CD4+ T cells expressed a novel cell surface phenotype (CCR7int/+ CD62Lint CD69− CD103+/− E-selectin ligands+), distinct from memory T cell subsets described to date. Unlike memory T cell subsets that remain resident within tissues long-term, or that migrate either exclusively between lymphoid tissues or into peripheral nonlymphoid sites, CD4+ TRCM migrate from the skin into draining LNs. From the draining LN, they reenter into the circulation, distal LNs and sites of non-specific cutaneous inflammation. Additionally, CD4+ TRCM up-regulated CD40L and secreted IL-2 following polyclonal stimulation. Together, our results identify a novel subset of recirculating memory CD4+ T cells equipped to deliver help to both distal lymphoid and cutaneous tissues.
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影响因子：
64.8
作者：
CEPEK, KL;SHAW, SK;BRENNER, MB
通讯作者：
BRENNER, MB
DOI：
10.1084/jem.171.3.801
发表时间：
1990-03-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Mackay CR;Marston WL;Dudler L
通讯作者：
Dudler L
影响因子：
32.4
作者：
Pham, Trung H. M.;Okada, Takaharu;Cyster, Jason G.
通讯作者：
Cyster, Jason G.
影响因子：
4.4
作者：
Suffia, I;Reckling, SK;Belkaid, Y
通讯作者：
Belkaid, Y
影响因子：
64.8
作者：
Jiang, Xiaodong;Clark, Rachael A.;Liu, Luzheng;Wagers, Amy J.;Fuhlbrigge, Robert C.;Kupper, Thomas S.
通讯作者：
Kupper, Thomas S.