Effect of electroacupuncture on rats with chronic constriction injury-induced neuropathic pain.
Effect of electroacupuncture on rats with chronic constriction injury-induced neuropathic pain.
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DOI：
10.1155/2014/129875
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发表时间：
2014
影响因子：
--
通讯作者：
Hsieh CL
中科院分区：
文献类型：
--
作者：
Hsu HC;Tang NY;Lin YW;Li TC;Liu HJ;Hsieh CL
我们采用慢性压迫性损伤（CCI）模型，通过使用四根4-0铬肠线结扎右侧坐骨神经，然后分别对右侧（同侧）足三里（St-36）和上巨虚（St-37）应用2和15 Hz电针（EA），对Spragrue-Dawley（SD）大鼠诱导神经性疼痛 穴位。本研究结果总结如下：（1）对照组（即非电针组）和假手术组的辐射热测试的缩回潜伏期和冷板测试（4°C）的总抬腿计数差异大于2 Hz EA（2EA）和15 Hz EA（15EA）组； (2)结扎后第6、7、8、11、12、13天，对照组和假手术组的von Frey试验丝克数均少于2EA和15EA组； (3) 2EA 和 15EA 组表现出大脑瞬时受体电位香草酸 4 型 (TRPV4) 表达减少，尽管我们没有观察到大脑 TRPV1 或脊髓 TRPV4/TRPV1 表达的类似作用。这些发现表明，2 和 15 Hz EA 可以减轻 CCI 引起的神经性疼痛，这表明各种脊柱节段和门效应在减轻疼痛方面具有至关重要的功能。 EA与TRPV4/TRPV1表达之间的关系需要进一步研究。
We adopt the chronic constriction injury (CCI) model to induce neuropathic pain to Spragrue-Dawley (SD) rats by ligating the right sciatic nerve of using four 4-0 chromic gut sutures and subsequently applying 2 and 15 Hz electroacupuncture (EA), respectively, to the right (ipsilateral) Zusanli (St-36) and Shangjuxu (St-37) acupoints. The results of this study are summarized as follows: (1) the differences in withdrawal latencies for the radiant heat test and total lift leg counts for the cold plate test (4°C) of the control (i.e., non-EA) and sham groups were greater than those of the 2 Hz EA (2EA) and 15 Hz EA (15EA) groups; (2) the von Frey test filament gram counts of the control and sham groups were less than those of the 2EA and 15EA groups on the 6th, 7th, 8th, 11th, 12th, and 13th day following ligation; and (3) the 2EA and 15EA groups exhibited reduced cerebral transient receptor potential vanilloid type 4 (TRPV4) expressions, although we did not observe a similar effect for cerebral TRPV1 or spinal TRPV4/TRPV1 expressions. These findings show that 2 and 15 Hz EA can reduce CCI-induced neuropathic pain, which indicates that various spinal segmental and gate effects have a crucial function in pain reduction. The relationship between EA and TRPV4/TRPV1 expression requires further study.
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影响因子：
5.3
作者：
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