Fluorescent Magnetic Nanoprobes for in vivo Targeted Imaging and Hyperthermia Therapy of Prostate Cancer
Fluorescent Magnetic Nanoprobes for in vivo Targeted Imaging and Hyperthermia Therapy of Prostate Cancer
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用于前列腺癌体内靶向成像和热疗的荧光磁性纳米探针
DOI：
10.5101/nbe.v1i1.p61-74
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
崔大祥
中科院分区：
文献类型：
--
作者：
崔大祥
开发用于前列腺癌靶向成像和选择性治疗的无毒纳米探针是一项具有挑战性的任务。在此，将直径为50纳米的荧光超顺磁性纳米粒子与针对……的单链Fv抗体结合。
It has been a challenging task to develop nontoxic nanoprobes for targeted-imaging and selective therapy of prostate cancer. Herein, fluorescent superparamagnetic nanoparticles with a diameter of 50 nm were conjugated with single-chain Fv antibody against g -seminoprotein. The resultant nanoprobes showed highly selective targeting, fluorescent imaging, and magnetic resonance imaging. The cytotoxicity effects were investigated on the prostate cancer cells and solid tumors under in vitro alternating magnetic field irradiation. It was found that the as-prepared nanoprobes did not show signs of toxicity within the used maximal dosage . It was also observed that the tumors implanted in nude mice were significantly reduced in size and disappeared gradually due to thermal treatment. The lifespan of post-therapeutic mice loaded with prostate cancer was considerable prolonged. High-performance single-chain Fv antibody against g -seminoprotein-conjugated fluorescent magnetic nanoparticles may have great potential in applications such early detection and localized thermal therapy of prostate cancer.
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DOI：
10.1891/9780826121646.0002
发表时间：
2018-09
期刊：
Cancer Rehabilitation
影响因子：
--
作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
通讯作者：
K. Miller;R. Siegel;R. Khan;A. Jemal
影响因子：
2
作者：
D. Tilki;M. Seitz;B. Singer;S. Irmak;C. Stief;O. Reich;S. Ergün
通讯作者：
D. Tilki;M. Seitz;B. Singer;S. Irmak;C. Stief;O. Reich;S. Ergün
影响因子：
29.4
作者：
Yang L;Mao H;Cao Z;Wang YA;Peng X;Wang X;Sajja HK;Wang L;Duan H;Ni C;Staley CA;Wood WC;Gao X;Nie S
通讯作者：
Nie S
纳米技术与医学
影响因子：
1.9
作者：
J. Baker
通讯作者：
J. Baker
影响因子：
3.1
作者：
R. Xu;S. Povoski
通讯作者：
R. Xu;S. Povoski