The effect of thermal therapy on the blood-brain barrier and blood-tumor barrier.
The effect of thermal therapy on the blood-brain barrier and blood-tumor barrier.
复制标题
热疗法对血脑屏障和血肿瘤屏障的影响。
DOI：
10.1080/02656736.2020.1783461
复制
发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Kim AH
中科院分区：
文献类型：
--
作者：
Patel B;Yang PH;Kim AH
血-脑和血-肿瘤屏障是高度专门化的结构，负责严格调控分子进入中枢神经系统。在正常情况下，血脑屏障(BBB)的相对不通透性保护大脑免受循环毒素的影响，并有助于创造最佳神经功能所需的大脑微环境。然而，在肿瘤和其他中枢神经系统疾病的背景下，血脑屏障和最近得到重视的血液-肿瘤屏障(BTB)是阻碍有效药物输送的障碍。克服这两个障碍以优化中枢神经系统疾病的治疗仍然是密集的科学研究的主题。虽然已经开发了许多较新的技术来克服这些障碍，但可以追溯到19世纪90年代的热疗至少从20世纪80年代初就已经被认为是破坏血脑屏障的方法。近年来，由于几项技术的进步，激光间质热疗(LIT)作为一种提供靶向热疗的方法，已被广泛用于脑肿瘤的外科治疗。此外，越来越多的证据表明，激光消融还可以增加治疗后局部BBB/BTB的通透性。本文就血脑屏障和血脑屏障的结构和功能以及热损伤对屏障功能的影响作一综述。
The blood-brain and blood-tumor barriers represent highly specialized structures responsible for tight regulation of molecular transit into the central nervous system. Under normal circumstances, the relative impermeability of the blood-brain barrier (BBB) protects the brain from circulating toxins and contributes to a brain microenvironment necessary for optimal neuronal function. However, in the context of tumors and other diseases of central nervous system, the BBB and the more recently appreciated blood-tumor barrier (BTB) represent barriers that prevent effective drug delivery. Overcoming both barriers to optimize treatment of central nervous system diseases remains the subject of intense scientific investigation. Although many newer technologies have been developed to overcome these barriers, thermal therapy, which dates back to the 1890s, has been known to disrupt the BBB since at least the early 1980s. Recently, as a result of several technological advances, laser interstitial thermal therapy (LITT), a method of delivering targeted thermal therapy, has gained widespread use as a surgical technique to ablate brain tumors. In addition, accumulating evidence indicates that laser ablation may also increase local BBB/BTB permeability after treatment. We herein review the structure and function of the BBB and BTB and the impact of thermal injury, including LITT, on barrier function.
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DOI：
10.1016/j.bbrc.2018.02.149
发表时间：
2018-03-04
影响因子：
3.1
作者：
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影响因子：
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25
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