The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy.
The Glyoxalase System in Age-Related Diseases: Nutritional Intervention as Anti-Ageing Strategy.
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与年龄有关的疾病中的糖酶系统：营养干预作为抗衰老策略。
DOI：
10.3390/cells10081852
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发表时间：
2021-07-22
期刊：
影响因子：
6
通讯作者：
Bejarano E
中科院分区：
文献类型：
--
作者：
Aragonès G;Rowan S;Francisco SG;Whitcomb EA;Yang W;Perini-Villanueva G;Schalkwijk CG;Taylor A;Bejarano E
糖苷酶系统对于晚期糖基化终产物（AGEs）的解毒至关重要。AGEs是一种有毒化合物，由糖或其代谢产物通过称为糖化的过程对生物分子进行非酶促修饰而产生。AGEs对许多组织有不良影响，在分子和细胞衰老的进展中起致病作用。由于不同的抗AGE机制（包括解毒机制和蛋白水解能力）与年龄相关的下降，糖化生物分子在我们身体的正常衰老过程中以组织依赖性方式积累。以这种方式来看，抗AGE解毒系统被提出作为治疗靶点，以对抗与AGE积累和细胞毒性相关的病理性功能障碍。在这里，我们总结了目前的知识状态有关的保护机制，对应激，特别强调的glycoprotein酶系统的主要机制解毒的反应性中间体的糖化。本文综述了谷胱甘肽酶系统的第一个酶，谷胱甘肽酶1（GLO1），以及这一催化过程的限速酶。尽管GLO1广泛表达，但蛋白质水平和活性以组织依赖性方式调节。我们提供了GLO1蛋白在不同组织中的比较分析。我们的研究结果表明，在眼睛视网膜，一个高含氧组织与快速蛋白质周转的内稳态的作用，谷胱甘肽酶系统。我们还描述了作为治疗靶点的谷胱甘肽酶系统的调节，以延缓年龄相关疾病的发展，并总结了描述具有调节谷胱甘肽酶系统的特性的营养化合物的现有知识的文献。
The glyoxalase system is critical for the detoxification of advanced glycation end-products (AGEs). AGEs are toxic compounds resulting from the non-enzymatic modification of biomolecules by sugars or their metabolites through a process called glycation. AGEs have adverse effects on many tissues, playing a pathogenic role in the progression of molecular and cellular aging. Due to the age-related decline in different anti-AGE mechanisms, including detoxifying mechanisms and proteolytic capacities, glycated biomolecules are accumulated during normal aging in our body in a tissue-dependent manner. Viewed in this way, anti-AGE detoxifying systems are proposed as therapeutic targets to fight pathological dysfunction associated with AGE accumulation and cytotoxicity. Here, we summarize the current state of knowledge related to the protective mechanisms against glycative stress, with a special emphasis on the glyoxalase system as the primary mechanism for detoxifying the reactive intermediates of glycation. This review focuses on glyoxalase 1 (GLO1), the first enzyme of the glyoxalase system, and the rate-limiting enzyme of this catalytic process. Although GLO1 is ubiquitously expressed, protein levels and activities are regulated in a tissue-dependent manner. We provide a comparative analysis of GLO1 protein in different tissues. Our findings indicate a role for the glyoxalase system in homeostasis in the eye retina, a highly oxygenated tissue with rapid protein turnover. We also describe modulation of the glyoxalase system as a therapeutic target to delay the development of age-related diseases and summarize the literature that describes the current knowledge about nutritional compounds with properties to modulate the glyoxalase system.
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水杨酸盐和吡id胺对糖尿病性肾病的预防作用。
影响因子：
4.3
作者：
Abouzed TK;Munesue S;Harashima A;Masuo Y;Kato Y;Khailo K;Yamamoto H;Yamamoto Y
通讯作者：
Yamamoto Y
DOI：
10.3390/antiox9111062
发表时间：
2020-10-30
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
Aragonès G;Rowan S;G Francisco S;Yang W;Weinberg J;Taylor A;Bejarano E
通讯作者：
Bejarano E
影响因子：
56.9
作者：
Bonifati, V;Rizzu, P;Heutink, P
通讯作者：
Heutink, P
影响因子：
8.2
作者：
Berner, A. K.;Brouwers, O.;Stitt, A. W.
通讯作者：
Stitt, A. W.
影响因子：
5.9
作者：
Alfarano M;Pastore D;Fogliano V;Schalkwijk CG;Oliviero T
通讯作者：
Oliviero T