Pediatric burden and seasonality of human metapneumovirus over 5 years in Managua, Nicaragua.
Pediatric burden and seasonality of human metapneumovirus over 5 years in Managua, Nicaragua.
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DOI：
10.1111/irv.13034
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发表时间：
2022-11
影响因子：
4.4
通讯作者：
Gordon, Aubree
中科院分区：
文献类型：
--
作者：
Hacker, Kathryn;Kuan, Guillermina;Vydiswaran, Nivea;Chowell-Puente, Gerardo;Patel, Mayuri;Sanchez, Nery;Lopez, Roger;Ojeda, Sergio;Lopez, Brenda;Mousa, Jarrod;Maier, Hannah E.;Balmaseda, Angel;Gordon, Aubree
人偏肺病毒(HMPV)是引起儿童呼吸道感染的重要原因。我们利用尼加拉瓜儿童流感队列研究(NPICS)来评估儿童中有症状的HMPV感染的负担和季节性。NPICS是一项正在进行的对尼加拉瓜马那瓜儿童的前瞻性研究。我们通过实时逆转录聚合酶链式反应(RT-PCR)评估儿童hMPV感染情况。我们使用经典的加性分解分析来评估时间趋势，并使用广义生长模型(GGMS)来估计有效繁殖数。2011-2016年间，共有564例HMPV症状性感染，发病率为5.74例/100人年(95%可信区间5.3，6.2)。儿童急性下呼吸道感染3509例，其中160例(4.6%)与hMPV感染有关。在所有有症状的人乳头瘤病毒感染中，1岁以下儿童有55%(62/112)发展为与人乳头瘤病毒相关的急性呼吸道感染，1岁以上儿童患与人乳头瘤病毒相关的急性呼吸道感染的可能性是1岁以上儿童的5倍(比率为5.5 95%CI 4.1，7.4p <； 0.001)。此外，有症状的hMPV再感染也很常见。总体而言，在所有观察到的有症状感染中，有87例(15%)被检测到再次感染。有症状的HMPV暴发的季节性差异很大。从2011年到2016年，观察到了四个流行期，遵循两年一次的季节性模式。流行期平均上升阶段为7.7周，总体平均估计繁殖数为1.2(95%可信区间1.1，1.4)。有症状的hMPV感染与生命第一年儿童的沉重负担有关。有症状的hMPV发生的时间和频率遵循两年一次的模式。
Human metapneumovirus (hMPV) is an important cause of pediatric respiratory infection. We leveraged the Nicaraguan Pediatric Influenza Cohort Study (NPICS) to assess the burden and seasonality of symptomatic hMPV infection in children. NPICS is an ongoing prospective study of children in Managua, Nicaragua. We assessed children for hMPV infection via real‐time reverse‐transcription polymerase chain reaction (RT‐PCR). We used classical additive decomposition analysis to assess the temporal trends, and generalized growth models (GGMs) were used to estimate effective reproduction numbers. From 2011 to 2016, there were 564 hMPV symptomatic infections, yielding an incidence rate of 5.74 cases per 100 person‐years (95% CI 5.3, 6.2). Children experienced 3509 acute lower respiratory infections (ALRIs), of which 160 (4.6%) were associated with hMPV infection. Children under the age of one had 55% of all symptomatic hMPV infections (62/112) develop into hMPV‐associated ALRIs and were five times as likely as children over one to have an hMPV‐associated ALRI (rate ratio 5.5 95% CI 4.1, 7.4 p < 0.001). Additionally, symptomatic reinfection with hMPV was common. In total, 87 (15%) of all observed symptomatic infections were detected reinfections. The seasonality of symptomatic hMPV outbreaks varied considerably. From 2011 to 2016, four epidemic periods were observed, following a biennial seasonal pattern. The mean ascending phase of the epidemic periods were 7.7 weeks, with an overall mean estimated reproductive number of 1.2 (95% CI 1.1, 1.4). Symptomatic hMPV infection was associated with substantial burden among children in the first year of life. Timing and frequency of symptomatic hMPV incidence followed biennial patterns.
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影响因子：
11.8
作者：
Huck B;Scharf G;Neumann-Haefelin D;Puppe W;Weigl J;Falcone V
通讯作者：
Falcone V
影响因子：
11.8
作者：
Lim, Yong Kwan;Kweon, Oh Joo;Lee, Mi-Kyung
通讯作者：
Lee, Mi-Kyung
影响因子：
3.2
作者：
Arnott, Alicia;Vong, Sirenda;Buchy, Philippe
通讯作者：
Buchy, Philippe
DOI：
10.1056/nejmoa1204630
发表时间：
2013-02-14
期刊：
The New England journal of medicine
影响因子：
--
作者：
Edwards KM;Zhu Y;Griffin MR;Weinberg GA;Hall CB;Szilagyi PG;Staat MA;Iwane M;Prill MM;Williams JV;New Vaccine Surveillance Network
通讯作者：
New Vaccine Surveillance Network
影响因子：
11.8
作者：
Cuevas, LE;Ben Nasser, AM;Hart, CA
通讯作者：
Hart, CA