Abnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients.
Abnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients.
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2型糖尿病患者膝关节软骨下骨重塑异常及其与关节软骨退化的关系
DOI：
10.1038/boneres.2017.34
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发表时间：
2017
期刊：
影响因子：
12.7
通讯作者：
Lu WW
中科院分区：
文献类型：
--
作者：
Chen Y;Huang YC;Yan CH;Chiu KY;Wei Q;Zhao J;Guo XE;Leung F;Lu WW
2型糖尿病（T2D）与全身异常骨重塑和骨质流失有关。同时，软骨下骨重构异常导致软骨退化，导致骨关节炎（OA）。因此，我们研究了T2D患者膝关节软骨下骨重塑、微观结构和强度的变化及其与软骨降解的关系。收集膝关节OA全膝关节置换术患者的胫骨平台，分为非糖尿病组（n= 70）和糖尿病组（n= 51）。胫骨平台也从尸体供体（n= 20）收集，并作为对照。采用显微计算机断层扫描评估软骨下骨微观结构。通过微有限元分析评估骨强度。用组织学方法估计软骨退化情况。免疫组化法计算抗酒石酸酸性磷酸酶（TRAP）、骨甾体和骨钙素的表达。国际骨关节炎研究协会（OARSI）评分在非糖尿病组和糖尿病组之间无差异，而糖尿病组内侧OARSI评分较高。糖尿病组双侧骨体积分数和骨小梁数均降低，结构模型指数升高。这些微观结构改变转化为糖尿病组较低的弹性模量。糖尿病组TRAP+破骨细胞数量较多，Osterix+成骨细胞和骨钙素+成骨细胞数量较少。T2D膝关节的特点是异常软骨下骨重塑和微结构和机械损伤，这与软骨退化加剧有关。在糖尿病组软骨完好的区域，下位骨仍存在异常重塑，提示异常骨重塑可能参与了t2dm相关性膝关节炎的早期发病机制。
Type 2 diabetes (T2D) is associated with systemic abnormal bone remodeling and bone loss. Meanwhile, abnormal subchondral bone remodeling induces cartilage degradation, resulting in osteoarthritis (OA). Accordingly, we investigated alterations in subchondral bone remodeling, microstructure and strength in knees from T2D patients and their association with cartilage degradation. Tibial plateaus were collected from knee OA patients undergoing total knee arthroplasty and divided into non-diabetic (n= 70) and diabetes (n= 51) groups. Tibial plateaus were also collected from cadaver donors (n= 20) and used as controls. Subchondral bone microstructure was assessed using micro-computed tomography. Bone strength was evaluated by micro-finite-element analysis. Cartilage degradation was estimated using histology. The expression of tartrate-resistant acidic phosphatase (TRAP), osterix, and osteocalcin were calculated using immunohistochemistry. Osteoarthritis Research Society International (OARSI) scores of lateral tibial plateau did not differ between non-diabetic and diabetes groups, while higher OARSI scores on medial side were detected in diabetes group. Lower bone volume fraction and trabecular number and higher structure model index were found on both sides in diabetes group. These microstructural alterations translated into lower elastic modulus in diabetes group. Moreover, diabetes group had a larger number of TRAP+ osteoclasts and lower number of Osterix+ osteoprogenitors and Osteocalcin+ osteoblasts. T2D knees are characterized by abnormal subchondral bone remodeling and microstructural and mechanical impairments, which were associated with exacerbated cartilage degradation. In regions with intact cartilage the underlying bone still had abnormal remodeling in diabetes group, suggesting that abnormal bone remodeling may contribute to the early pathogenesis of T2D-associated knee OA.
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影响因子：
6.2
作者：
Liu, X. Sherry;Wang, Ji;Zhou, Bin;Stein, Emily;Shi, Xiutao;Adams, Mark;Shane, Elizabeth;Guo, X. Edward
通讯作者：
Guo, X. Edward
影响因子：
4.8
作者：
Ganz ML;Wintfeld N;Li Q;Alas V;Langer J;Hammer M
通讯作者：
Hammer M
FFA-ROS-P53介导的线粒体凋亡有助于减少2型糖尿病中的成骨细胞生成和骨量
影响因子：
4.6
作者：
Li J;He W;Liao B;Yang J
通讯作者：
Yang J
DOI：
10.1302/0301-620x.85b6.12595
发表时间：
2003-08-01
影响因子：
--
作者：
Ding, M;Odgaard, A;Hvid, I
通讯作者：
Hvid, I
影响因子：
7
作者：
Crema, M. D.;Cibere, J.;Guermazi, A.
通讯作者：
Guermazi, A.