Detection and localization of surgically resectable cancers with a multi-analyte blood test.
Detection and localization of surgically resectable cancers with a multi-analyte blood test.
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DOI：
10.1126/science.aar3247
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发表时间：
2018-02-23
期刊：
影响因子：
--
通讯作者：
Papadopoulos N
中科院分区：
文献类型：
--
作者：
Cohen JD;Li L;Wang Y;Thoburn C;Afsari B;Danilova L;Douville C;Javed AA;Wong F;Mattox A;Hruban RH;Wolfgang CL;Goggins MG;Dal Molin M;Wang TL;Roden R;Klein AP;Ptak J;Dobbyn L;Schaefer J;Silliman N;Popoli M;Vogelstein JT;Browne JD;Schoen RE;Brand RE;Tie J;Gibbs P;Wong HL;Mansfield AS;Jen J;Hanash SM;Falconi M;Allen PJ;Zhou S;Bettegowda C;Diaz LA Jr;Tomasetti C;Kinzler KW;Vogelstein B;Lennon AM;Papadopoulos N
早期发现是减少癌症死亡的关键。在这里，我们描述了一种血液测试，可以通过评估循环蛋白质水平和无细胞DNA突变来检测八种常见的癌症类型。我们将这种称为CancerSEEK的测试应用于1005名患有非转移性、临床检测到的卵巢癌、肝癌、胃癌、胰腺癌、食道癌、结直肠癌、肺癌或乳腺癌的患者。CancerSEEK测试在八种癌症类型中的中位数为70%。检测五种癌症类型（卵巢癌、肝癌、胃癌、胰腺癌和食道癌）的灵敏度范围为69%至98%，对于这些癌症类型，平均风险个体没有可用的筛查测试。CancerSEEK的特异性大于99%：812名健康对照中只有7名得分为阳性。此外，CancerSEEK将癌症定位于少数解剖部位，中位数为83%。
Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.
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DOI：
10.1073/pnas.0507904102
发表时间：
2005-11-08
影响因子：
11.1
作者：
Diehl, F;Li, M;Vogelstein, B
通讯作者：
Vogelstein, B
影响因子：
7.7
作者：
Bozic I;Reiter JG;Allen B;Antal T;Chatterjee K;Shah P;Moon YS;Yaqubie A;Kelly N;Le DT;Lipson EJ;Chapman PB;Diaz LA Jr;Vogelstein B;Nowak MA
通讯作者：
Nowak MA
影响因子：
64.8
作者：
Abbosh C;Birkbak NJ;Wilson GA;Jamal-Hanjani M;Constantin T;Salari R;Le Quesne J;Moore DA;Veeriah S;Rosenthal R;Marafioti T;Kirkizlar E;Watkins TBK;McGranahan N;Ward S;Martinson L;Riley J;Fraioli F;Al Bakir M;Grönroos E;Zambrana F;Endozo R;Bi WL;Fennessy FM;Sponer N;Johnson D;Laycock J;Shafi S;Czyzewska-Khan J;Rowan A;Chambers T;Matthews N;Turajlic S;Hiley C;Lee SM;Forster MD;Ahmad T;Falzon M;Borg E;Lawrence D;Hayward M;Kolvekar S;Panagiotopoulos N;Janes SM;Thakrar R;Ahmed A;Blackhall F;Summers Y;Hafez D;Naik A;Ganguly A;Kareht S;Shah R;Joseph L;Marie Quinn A;Crosbie PA;Naidu B;Middleton G;Langman G;Trotter S;Nicolson M;Remmen H;Kerr K;Chetty M;Gomersall L;Fennell DA;Nakas A;Rathinam S;Anand G;Khan S;Russell P;Ezhil V;Ismail B;Irvin-Sellers M;Prakash V;Lester JF;Kornaszewska M;Attanoos R;Adams H;Davies H;Oukrif D;Akarca AU;Hartley JA;Lowe HL;Lock S;Iles N;Bell H;Ngai Y;Elgar G;Szallasi Z;Schwarz RF;Herrero J;Stewart A;Quezada SA;Peggs KS;Van Loo P;Dive C;Lin CJ;Rabinowitz M;Aerts HJWL;Hackshaw A;Shaw JA;Zimmermann BG;TRACERx consortium;PEACE consortium;Swanton C
通讯作者：
Swanton C
DOI：
10.1073/pnas.0712345105
发表时间：
2008-03-18
影响因子：
11.1
作者：
Jones, Sian;Chen, Wei-dong;Markowitz, Sanford D.
通讯作者：
Markowitz, Sanford D.
影响因子：
28.2
作者：
Haber DA;Velculescu VE
通讯作者：
Velculescu VE