A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects.
A randomized placebo-controlled cross-over study on the effects of anthocyanins on inflammatory and metabolic responses to a high-fat meal in healthy subjects.
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DOI：
10.1016/j.redox.2022.102273
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发表时间：
2022-05
期刊：
影响因子：
11.4
通讯作者：
Oteiza PI
中科院分区：
文献类型：
--
作者：
Cremonini E;Daveri E;Iglesias DE;Kang J;Wang Z;Gray R;Mastaloudis A;Kay CD;Hester SN;Wood SM;Fraga CG;Oteiza PI
本研究调查了补充富含花青素和飞燕草素的提取物 (CDRE) 对健康个体因食用高脂餐 (HFM) 引发的餐后代谢障碍、炎症以及氧化还原和胰岛素信号的影响。参与者（n = 25）同时消耗 1026 kcal HFM 和提供 320.4 mg 花青素（90% 花青素和飞燕草素）的 CDRE 或安慰剂。饮食以双盲、安慰剂对照的交叉设计随机分配。在进食前（空腹，时间 0）和进食后 5 小时采集血液；分离血浆、血清和外周血单核细胞（PBMC）。消耗 CDRE 后 30 分钟即可在血清中检测到 AC 代谢物。 CDRE 减轻了 HFM 诱导的内毒素血症，减少血浆 LPS 和 LPS 结合蛋白的增加。 CDRE 还减少了与 HFM 引发的餐后代谢异常相关的其他事件，包括： i) 血浆葡萄糖和甘油三酯升高； ii) PBMC 中 TNFα 和 NOX4 上调； iii) PBMC 中的 JNK1/2 激活。 CDRE 不会显着影响 HFM 介导的血浆胰岛素、GLP-1、GLP-2、GIP、LDL-和 HDL-胆固醇以及 PBMC 中 IKK 磷酸化的增加。总之，膳食AC，即花青素和飞燕草素，通过调节相关的餐后代谢障碍、内毒素血症、血糖和血脂的改变以及氧化还原和胰岛素信号传导，对不健康饮食发挥有益作用。
This study investigated the effects of supplementation with a cyanidin- and delphinidin-rich extract (CDRE) on the postprandial dysmetabolism, inflammation, and redox and insulin signaling, triggered by the consumption of a high fat meal (HFM) in healthy individuals. Participants (n = 25) consumed a 1026-kcal HFM simultaneously with either the CDRE providing 320.4 mg of anthocyanins (90% cyanidin and delphinidin) or placebo. Diets were randomly assigned in a double blind, placebo-controlled crossover design. Blood was collected prior to (fasted, time 0), and for 5 h after meal consumption; plasma, serum, and peripheral blood mononuclear cells (PBMC) were isolated. AC metabolites were detected in serum as early as 30 min after CDRE consumption. The CDRE mitigated HFM-induced endotoxemia, reducing increases in plasma LPS and LPS-binding protein. The CDRE also reduced other events associated with HFM-triggered postprandial dysmetabolism including: i) plasma glucose and triglyceride increases; ii) TNFα and NOX4 upregulation in PBMC; and iii) JNK1/2 activation in PBMC. The CDRE did not significantly affect HFM-mediated increases in plasma insulin, GLP-1, GLP-2, GIP, and LDL- and HDL-cholesterol, and IKK phosphorylation in PBMC. In summary, dietary AC, i.e. cyanidin and delphinidin, exerted beneficial actions against unhealthy diets by modulating the associated postprandial dysmetabolism, endotoxemia, alterations of glycemia and lipidemia, and redox and insulin signaling.
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