The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.
The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.
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DOI：
10.1016/j.cels.2017.11.001
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发表时间：
2018-01-24
期刊：
影响因子：
9.3
通讯作者：
Pillai A
中科院分区：
文献类型：
--
作者：
Keenan AB;Jenkins SL;Jagodnik KM;Koplev S;He E;Torre D;Wang Z;Dohlman AB;Silverstein MC;Lachmann A;Kuleshov MV;Ma'ayan A;Stathias V;Terryn R;Cooper D;Forlin M;Koleti A;Vidovic D;Chung C;Schürer SC;Vasiliauskas J;Pilarczyk M;Shamsaei B;Fazel M;Ren Y;Niu W;Clark NA;White S;Mahi N;Zhang L;Kouril M;Reichard JF;Sivaganesan S;Medvedovic M;Meller J;Koch RJ;Birtwistle MR;Iyengar R;Sobie EA;Azeloglu EU;Kaye J;Osterloh J;Haston K;Kalra J;Finkbiener S;Li J;Milani P;Adam M;Escalante-Chong R;Sachs K;Lenail A;Ramamoorthy D;Fraenkel E;Daigle G;Hussain U;Coye A;Rothstein J;Sareen D;Ornelas L;Banuelos M;Mandefro B;Ho R;Svendsen CN;Lim RG;Stocksdale J;Casale MS;Thompson TG;Wu J;Thompson LM;Dardov V;Venkatraman V;Matlock A;Van Eyk JE;Jaffe JD;Papanastasiou M;Subramanian A;Golub TR;Erickson SD;Fallahi-Sichani M;Hafner M;Gray NS;Lin JR;Mills CE;Muhlich JL;Niepel M;Shamu CE;Williams EH;Wrobel D;Sorger PK;Heiser LM;Gray JW;Korkola JE;Mills GB;LaBarge M;Feiler HS;Dane MA;Bucher E;Nederlof M;Sudar D;Gross S;Kilburn DF;Smith R;Devlin K;Margolis R;Derr L;Lee A;Pillai A
基于综合网络的细胞特征库（LINCS）是美国国立卫生研究院的一个共同基金项目，它编目了人类细胞如何对化学、遗传和疾病扰动做出全球反应。LINCS生成的资源包括实验和计算方法、可视化工具、分子和成像数据以及签名。通过整合人类细胞在多种扰动下的反应范围，LINCS项目旨在更好地了解人类疾病并推进新疗法的开发。研究中的扰动包括药物、遗传扰动、组织微环境、抗体和致病突变。对扰动的反应通过转录谱分析、质谱分析、细胞成像和生化方法以及其他分析来测量。LINCS项目侧重于与一系列疾病（包括癌症、心脏病和神经退行性疾病）相关的组织和细胞类型之间共享的细胞生理学。本展望描述了LINCS技术、数据集、工具以及数据可访问性和可重用性的方法。
The Library of Integrated Network-based Cellular Signatures (LINCS) is an NIH Common Fund program that catalogs how human cells globally respond to chemical, genetic and disease perturbations. Resources generated by LINCS include experimental and computational methods, visualization tools, molecular and imaging data, and signatures. By assembling an integrated picture of the range of responses of human cells exposed to many perturbations, the LINCS program aims to better understand human disease and to advance the development of new therapies. Perturbations under study include drugs, genetic perturbations, tissue micro-environments, antibodies, and disease-causing mutations. Responses to perturbations are measured by transcript profiling, mass spectrometry, cell imaging, and biochemical methods, among other assays. The LINCS program focuses on cellular physiology shared among tissues and cell types relevant to an array of diseases, including cancer, heart disease, and neurodegenerative disorders. This Perspective describes LINCS technologies, datasets, tools, and approaches to data accessibility and reusability.
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关于癌症基因组地图集的泛伴奏蛋白质组学观点。
影响因子：
16.6
作者：
Akbani, Rehan;Ng, Patrick Kwok Shing;Werner, Henrica M. J.;Shahmoradgoli, Maria;Zhang, Fan;Ju, Zhenlin;Liu, Wenbin;Yang, Ji-Yeon;Yoshihara, Kosuke;Li, Jun;Ling, Shiyun;Seviour, Elena G.;Ram, Prahlad T.;Minna, John D.;Diao, Lixia;Tong, Pan;Heymach, John V.;Hill, Steven M.;Dondelinger, Frank;Stadler, Nicolas;Byers, Lauren A.;Meric-Bernstam, Funda;Weinstein, John N.;Broom, Bradley M.;Verhaak, Roeland G. W.;Liang, Han;Mukherjee, Sach;Lu, Yiling;Mills, Gordon B.
通讯作者：
Mills, Gordon B.
影响因子：
3
作者：
Clark NR;Hu KS;Feldmann AS;Kou Y;Chen EY;Duan Q;Ma'ayan A
通讯作者：
Ma'ayan A
影响因子：
14.9
作者：
Kuleshov MV;Jones MR;Rouillard AD;Fernandez NF;Duan Q;Wang Z;Koplev S;Jenkins SL;Jagodnik KM;Lachmann A;McDermott MG;Monteiro CD;Gundersen GW;Ma'ayan A
通讯作者：
Ma'ayan A
DOI：
10.1136/amiajnl-2014-002974
发表时间：
2014-11
期刊：
Journal of the American Medical Informatics Association : JAMIA
影响因子：
--
作者：
Margolis R;Derr L;Dunn M;Huerta M;Larkin J;Sheehan J;Guyer M;Green ED
通讯作者：
Green ED
影响因子：
7
作者：
Abelin, Jennifer G.;Patel, Jinal;Jaffe, Jacob D.
通讯作者：
Jaffe, Jacob D.