Tissue distribution of organochlorine pesticides in largemouth bass (Micropterus salmoides) from laboratory exposure and a contaminated lake.
Tissue distribution of organochlorine pesticides in largemouth bass (Micropterus salmoides) from laboratory exposure and a contaminated lake.
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DOI：
10.1016/j.envpol.2016.06.061
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发表时间：
2016-09
影响因子：
8.9
通讯作者：
Denslow, Nancy D.
中科院分区：
文献类型：
--
作者：
Dang, Viet D.;Kroll, Kevin J.;Supowit, Samuel D.;Flalden, Rolf U.;Denslow, Nancy D.
组织浓度的持久性有机氯农药在实验室暴露的大口鲈鱼（Micropterus salmoides）和鲈鱼从Apopka湖，佛罗里达州收集的总质量和脂质标准化质量，以更好地了解污染物的生物累积途径。在实验室研究中，雄性鲈鱼口服单剂量的两种杀虫剂（p，p '-二氯二苯基二氯乙烯（p，p'-DDE）和狄氏剂）的混合物，然后喂食未受污染的食物28天。采集胃肠道、肝脏、脑、性腺、肾脏、脾脏和肌肉进行化学分析。与脂质标准化质量相比，通过组织中的总质量观察到不同的特征。在脂质标准化的基础上，p，p '-DDE在胃肠道中最高，其次是肝脏、性腺、脾脏、肌肉、肾脏，然后是大脑。另一方面，狄氏剂在胃肠道和脾脏中含量最高，其次是性腺、肌肉、肝脏、肾脏和大脑。化学物质在器官中的分布因其log KOW而异，通常遵循胃肠道后的血流路径。肾脏和脑中的低水平表明，这些组织中的平衡时间不足，尤其是进入脑中，因为脑中的血脑屏障可能难以穿过。在Apopka湖鱼中发现了二氯二苯基三氯乙烷（DDXs，p，p '-DDE、p，p'-DDD和p，p '-DDT的总和）、Drins（艾氏剂、狄氏剂和异狄氏剂的总和）和六氯环己烷（HCHs）。对于Drins和六氯环己烷，肾脏、脾脏、大脑、性腺和肌肉中的脂质标准化浓度相似，但胃肠道和肝脏中的浓度要低得多，这可能是因为在这些组织中发生了新陈代谢。
Tissue concentrations of persistent organochlorine pesticides in laboratory-exposed largemouth bass (Micropterus salmoides) and in bass collected from Lake Apopka, FL were determined by both total mass and lipid normalized mass to better understand the bioaccumulation pathways of contaminants. In the laboratory study, male bass were orally administered a single dose of a mixture of two pesticides (p, p’-dichlorodiphenyldichloroethylene (p, p’-DDE) and dieldrin) and then fed uncontaminated food for 28 days. Gastrointestinal tract, liver, brain, gonad, kidney, spleen, and muscle were collected for chemical analysis. Different profiles were observed by total mass in tissues compared to lipid normalized mass. On a lipid normalized basis, p, p’-DDE was highest in the gastrointestinal tract followed by the liver, gonad, spleen, muscle, kidney and then brain. Dieldrin, on the other hand, was highest in the gastrointestinal tract and spleen and then followed by the gonad, muscle, liver, kidney and brain. Distribution of the chemicals to the organs differed by their log KOW and generally followed the blood flow path after the gastrointestinal tract. The low levels in kidney and brain suggest insufficient time for equilibration into these tissues, especially into the brain where the blood-brain barrier may be slow to traverse. In Lake Apopka fish, dichlorodiphenyltrichloroethanes (DDXs, sum of p, p’-DDE, p, p’-DDD, and p, p’-DDT), Drins (sum of aldrin, dieldrin, and endrin), and hexachlorocyclohexanes (HCHs) were found. For DDXs, the lipid normalized concentrations in each tissue were about the same, as predicted from theory. For Drins and HCHs, the lipid normalized concentrations were similar for kidney, spleen, brain, gonad and muscle, but much lower in the gastrointestinal tract and liver, probably because of metabolism occurring in those tissues.
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