Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop.
Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop.
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DOI：
10.1289/ehp.96104s4715
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发表时间：
1996-08
影响因子：
10.4
通讯作者：
Tilson HA
中科院分区：
文献类型：
--
作者：
Kavlock RJ;Daston GP;DeRosa C;Fenner-Crisp P;Gray LE;Kaattari S;Lucier G;Luster M;Mac MJ;Maczka C;Miller R;Moore J;Rolland R;Scott G;Sheehan DM;Sinks T;Tilson HA
已经提出的假设是，人类和野生动物物种在暴露于干扰内分泌的化学品后会受到不利的健康影响。报告的不良影响包括人口减少、癌症增加和生殖功能下降。美国环境保护署于1995年4月主办了一次讲习班，将有关各方聚集在一起，努力确定与这一假设有关的研究空白，并确定未来研究活动的优先事项。大约90名受邀参与者被组织成工作组，围绕报告的主要健康影响-致癌作用、生殖毒性、神经毒性和免疫毒性-以及沿着风险评估范例-危害识别、剂量反应评估、暴露评估和风险表征。注意力集中在生态和人类健康的影响。总体而言，专家组认为，这一假设需要进行协调一致的研究，以评估其有效性，研究应主要侧重于对生殖能力发育的影响、改进的接触评估以及混合物的影响。本报告总结了各工作组的讨论情况，并详细介绍了进一步研究的建议。
The hypothesis has been put forward that humans and wildlife species adverse suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects include declines in populations, increases in cancers, and reduced reproductive function. The U.S. Environmental Protection Agency sponsored a workshop in April 1995 to bring together interested parties in an effort to identify research gaps related to this hypothesis and to establish priorities for future research activities. Approximately 90 invited participants were organized into work groups developed around the principal reported health effects-carcinogenesis, reproductive toxicity, neurotoxicity, and immunotoxicity-as well as along the risk assessment paradigm-hazard identification, dose-response assessment, exposure assessment, and risk characterization. Attention focused on both ecological and human health effects. In general, group felt that the hypothesis warranted a concerted research effort to evaluate its validity and that research should focus primarily on effects on development of reproductive capability, on improved exposure assessment, and on the effects of mixtures. This report summarizes the discussions of the work groups and details the recommendations for additional research.
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影响因子：
10.4
作者：
BERGERON, JM;CREWS, D;MCLACHLAN, JA
通讯作者：
MCLACHLAN, JA
影响因子：
9.8
作者：
BAUMANN, PC;HARSHBARGER, JC;HARTMAN, KJ
通讯作者：
HARTMAN, KJ
影响因子：
2.7
作者：
BOWSER, DH;FRENKEL, K;ZELIKOFF, JT
通讯作者：
ZELIKOFF, JT
DOI：
10.1016/0272-0590(92)90139-9
发表时间：
1992-04-01
期刊：
FUNDAMENTAL AND APPLIED TOXICOLOGY
影响因子：
--
作者：
CHHABRA, RS;EUSTIS, S;CARLTON, BD
通讯作者：
CARLTON, BD
DOI：
10.1080/00039896.1987.9934355
发表时间：
1987-11-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
BROWN, DP
通讯作者：
BROWN, DP