A high-throughput screen targeting malaria transmission stages opens new avenues for drug development.
A high-throughput screen targeting malaria transmission stages opens new avenues for drug development.
复制标题
DOI：
10.1093/infdis/jir037
复制
发表时间：
2011-05-15
期刊：
影响因子：
--
通讯作者：
Marti M
中科院分区：
文献类型：
--
作者：
Buchholz K;Burke TA;Williamson KC;Wiegand RC;Wirth DF;Marti M
全球根除疟疾计划的一个主要目标是减少并最终消除疟疾传播。目前所有可用的抗疟疾化合物都是根据它们对寄生虫无性繁殖红血球阶段的活性而发现的，这些红血球阶段是导致人类疟疾发病率和死亡率的原因。对这些化合物的耐药性很普遍，迫切需要新的方法来减少对新抗疟疾药物引入时出现的耐药性。我们已经建立并验证了第一个针对传播所需的红细胞寄生虫阶段的高通量检测方法，即有性生殖的配子体。除了无性阶段的寄生虫外，这项检测还可以鉴定出专门针对传播阶段的化合物。这种阶段特定的化合物可以用于联合治疗，通过阻断患者可能选择的耐药寄生虫的传播来减少耐药性的出现。
A major goal of the worldwide malaria eradication program is the reduction and eventual elimination of malaria transmission. All currently available antimalarial compounds were discovered on the basis of their activity against the asexually reproducing red blood cell stages of the parasite, which are responsible for the morbidity and mortality of human malaria. Resistance against these compounds is widespread, and there is an urgent need for novel approaches to reduce the emergence of resistance to new antimalarials as they are introduced. We have established and validated the first high-throughput assay targeting the red blood cell parasite stage required for transmission, the sexually reproducing gametocyte. This assay will permit identification of compounds specifically targeting the transmission stages in addition to the asexual stage parasites. Such stage-specific compounds may be used in a combination therapy, reducing the emergence of resistance by blocking transmission of resistant parasites that may be selected in a patient.
登录
查看更多内容
影响因子：
2
作者：
Abiodun, Oyindamola O.;Gbotosho, Grace O.;Oduola, Ayoade M. J.
通讯作者：
Oduola, Ayoade M. J.
影响因子：
2.4
作者：
Healer, J;McGuinness, D;Riley, E
通讯作者：
Riley, E
DOI：
10.1073/pnas.0802982105
发表时间：
2008-07-01
影响因子：
11.1
作者：
Plouffe, David;Brinker, Achim;Winzeler, Elizabeth A.
通讯作者：
Winzeler, Elizabeth A.
影响因子：
168.9
作者：
Kaneko, A;Taleo, G;Björkman, A
通讯作者：
Björkman, A
影响因子：
64.8
作者：
KAUSHAL, DC;CARTER, R;KRISHNA, G
通讯作者：
KRISHNA, G