CoNaMad-Cohorte de Nacimiento de Madre de Dios/Madre de Dios Birth Cohort to Study Effects of in-utero Trace Metals Exposure in the Southern Peruvian Amazon.
CoNaMad-Cohorte de Nacimiento de Madre de Dios/Madre de Dios Birth Cohort to Study Effects of in-utero Trace Metals Exposure in the Southern Peruvian Amazon.
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DOI：
10.5334/aogh.3152
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发表时间：
2021
影响因子：
2.9
通讯作者：
Miranda JJ
中科院分区：
文献类型：
--
作者：
Pan WK;Weinhouse C;Ortiz EJ;Berky AJ;Fixsen E;Mallipudi A;Feingold BJ;Navio S;Rivera NA;Hsu-Kim H;Miranda JJ
宫内接触汞和其他微量金属对儿童健康和发育构成重大威胁，但手工和小规模金矿开采环境中的暴露和健康影响的定义不明确。我们描述了CONAMAD的研究设计，这是一个预期分娩队列，由居住在农村和城市周边的秘鲁亚马逊社区的经产妇女(18岁及以上)组成，暴露于ASGM。孕妇从秘鲁马德雷德迪奥斯四个地区的卫生站登记。数据是在注册、分娩和(计划)36-48个月时收集的。在注册时，获得用于汞评估、人口统计学和临床数据的头发样本。出生时，我们会采集静脉血和脐带血、胎盘、头发、脚趾甲和唾液。270名母亲在平均孕周20周时登记，不同地区的母亲特征没有差异。215名母亲在出生时被成功跟踪。共采集母血和脐带血标本214份，母婴毛发样本211份，胎盘样本212份，婴儿唾液样本210份，婴儿干血点214份。收集的数据将使我们能够检验我们关于孕妇营养不良改良率的基本假设：脐带血：母血总汞(THG)，脐带血：母发THG，以及婴儿：母发THG，以及化学混合物(汞、铅、镉)是否对婴儿神经发育有协同作用。CONAMAD的目的是收集和存储样本，以供未来与宫内汞暴露和儿童发育相关的处理和假设检验。我们已经完成了暴露评估，并将对母亲进行后续跟踪，以评估儿童早期发展的结果，包括发育延迟和生长。这些数据为ASGM流行的国家提供了对疾病机制、暴露预防和政策指导的见解。
In-utero exposure to mercury and other trace metals pose a significant threat to child health and development, but exposures and health impacts in artisanal and small-scale gold mining (ASGM) environments are poorly defined. We describe the CONAMAD study design, a prospective birth cohort consisting of multiparous women (18 and over) living in rural and peri-urban Peruvian Amazon communities exposed to ASGM. Pregnant women are enrolled from health posts across four zones of Madre de Dios, Peru. Data are collected at enrollment, childbirth, and (planned) 36-48 months. At enrollment, hair samples for mercury assessment, demographic and clinical data are obtained. At birth, we obtain venous and cord blood, placenta, hair, toenails, and saliva. Two hundred seventy mothers were enrolled at an average 20 weeks gestational age with no differences in maternal characteristics across zones. Two hundred fifteen mothers were successfully followed at birth. We obtained 214 maternal and cord blood samples, 211 maternal and 212 infant hair samples, 212 placenta samples, 210 infant saliva samples, and 214 infant dried blood spots. Data collected will allow for testing our primary hypotheses of maternal malnutrition modifying ratios of cord:maternal blood total mercury (tHg), cord blood:maternal hair tHg, and infant:maternal hair tHg, and whether chemical mixtures (Hg, Pb, Cd) have synergistic effects on infant neurodevelopment. CONAMAD is designed to collect and store samples for future processing and hypothesis testing associated with in-utero mercury exposure and child development. We have completed the exposure assessments and will conduct a follow-up of mothers to evaluate early child development outcomes, including developmental delay and growth. These data offer insights into disease mechanisms, exposure prevention, and policy guidance for countries where ASGM is prevalent.
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影响因子：
8.3
作者：
Feingold BJ;Berky A;Hsu-Kim H;Rojas Jurado E;Pan WK
通讯作者：
Pan WK
影响因子：
3.7
作者：
Cardenas, Andres;Koestler, Devin C.;Marsit, Carmen J.
通讯作者：
Marsit, Carmen J.
DOI：
10.1073/pnas.1318271110
发表时间：
2013-11-12
影响因子：
11.1
作者：
Asner, Gregory P.;Llactayo, William;Raez Luna, Ernesto
通讯作者：
Raez Luna, Ernesto
影响因子：
1.9
作者：
Chong, K. C.;Zhou, V. L.;Llanos, F.
通讯作者：
Llanos, F.
影响因子：
7.7
作者：
Bakulski, Kelly M.;Lee, HwaJin;Fallin, M. Daniele
通讯作者：
Fallin, M. Daniele