Symptom clusters predict risk of metabolic-syndrome and diabetes in midlife: the Study of Women's Health Across the Nation.
Symptom clusters predict risk of metabolic-syndrome and diabetes in midlife: the Study of Women's Health Across the Nation.
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DOI：
10.1016/j.annepidem.2021.02.011
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发表时间：
2021-06
影响因子：
5.6
通讯作者：
Harlow SD
中科院分区：
文献类型：
--
作者：
Reeves AN;Elliott MR;Brooks MM;Karvonen-Gutierrez CA;Bondarenko I;Hood MM;Harlow SD
Women’s cardio-metabolic risk increases in midlife. Previous work relating menopause symptoms to diabetes/Metabolic Syndrome (MetS) does not consider the adverse impact of multiple concurrent physical and psychological symptoms in midlife. Data are from 3097 participants in the Study of Women’s Health Across the Nation, a cohort of midlife women followed for over 20 years. Baseline latent symptom classes (LSC) were derived from 58 questions assessing physical, psychological and menopausal symptoms. Six identified LSCs ranged from 1 (most symptoms present at high severity) to 6 (few symptoms present at low severity). Accelerated failure time models estimated time to onset of type 2 diabetes and MetS for each LSC. Women with multiple high/moderate severity symptoms had an earlier onset of diabetes (13.2%, 14.1% and 20.8% earlier onset in LSCs 1, 2, 3, respectively) and MetS (15.5%, 13.0% and 19.7% earlier onset in LSCs 1, 2, 3, respectively) than women with few/low severity symptoms. Having multiple concurrent moderate to high intensity physical and psychological symptoms in midlife are associated with early onset of diabetes and MetS. Monitoring and subsequent intervention on a broad range of symptoms in midlife may significantly mitigate cardio-metabolic risk during this critical life stage.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
DOI：
10.1186/s40695-017-0021-y
发表时间：
2017-01-01
期刊：
Women's midlife health
影响因子：
--
作者：
Harlow, Sioban D;Karvonen-Gutierrez, Carrie;Reed, Barbara D
通讯作者：
Reed, Barbara D
DOI：
10.1258/mi.2010.010029
发表时间：
2010-09-01
期刊：
Menopause international
影响因子：
--
作者：
Fernandez-Alonso, Ana M;Cuadros, Jose L;Perez-Lopez, Faustino R
通讯作者：
Perez-Lopez, Faustino R
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
影响因子：
2.4
作者：
Day, Caroline
通讯作者：
Day, Caroline