Continuous flow biocatalysis.
Continuous flow biocatalysis.
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DOI：
10.1039/c7cs00906b
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发表时间：
2018-07-30
影响因子：
46.2
通讯作者：
Weiss GA
中科院分区：
文献类型：
--
作者：
Britton J ;Majumdar S ;Weiss GA
活性药物成分、增值化学品和材料的连续流合成在过去十年中发展迅速。化学制造业的这场革命源于新方法和新技术的创新。然而，该领域主要集中在合成有机化学上，并且在连续流动系统中使用生物催化剂现在才变得流行。虽然固定化酶和全细胞在分批系统中是常见的，但它们的连续流动对应物在过去两年中迅速增长。连续流系统提供改进的混合、质量传递、热控制、加压处理、减少变化、自动化、过程分析技术和在线纯化，生物催化和流动化学的结合打开了强大的新工艺窗口。本综述探讨了连续流生物催化剂，重点是新技术，酶，全细胞，辅因子回收和固定化方法，用于合成药物，增值化学品和材料。连续流动生物催化：将蛋白质的力量和连续流动相结合，以改善化学合成。
The continuous flow synthesis of active pharmaceutical ingredients, value-added chemicals, and materials has grown tremendously over the past ten years. This revolution in chemical manufacturing has resulted from innovations in both new methodology and technology. This field, however, has been predominantly focused on synthetic organic chemistry, and the use of biocatalysts in continuous flow systems is only now becoming popular. Although immobilized enzymes and whole cells in batch systems are common, their continuous flow counterparts have grown rapidly over the past two years. With continuous flow systems offering improved mixing, mass transfer, thermal control, pressurized processing, decreased variation, automation, process analytical technology, and in-line purification, the combination of biocatalysis and flow chemistry opens powerful new process windows. This Review explores continuous flow biocatalysts with emphasis on new technology, enzymes, whole cells, co-factor recycling, and immobilization methods for the synthesis of pharmaceuticals, value-added chemicals, and materials. Continuous Flow Biocatalysis: Merging the power of proteins and continuous flow for improved chemical synthesis.
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影响因子：
4.9
作者：
Beauchamp J;Vieille C
通讯作者：
Vieille C
使用连续流化学的合成活性药物成分（API）。
影响因子：
2.7
作者：
Baumann M;Baxendale IR
通讯作者：
Baxendale IR
影响因子：
3
作者：
Brigida, Ana I. S.;Pinheiro, Alvaro D. T.;Goncalves, Luciana R. B.
通讯作者：
Goncalves, Luciana R. B.
影响因子：
4.3
作者：
Babich, Lara;Hartog, Aloysius F.;Wever, Ron
通讯作者：
Wever, Ron
影响因子：
4.9
作者：
Bao, Jennifer;Tranmer, Geoffrey K.
通讯作者：
Tranmer, Geoffrey K.