Fast low‐angle shot diffusion tensor imaging with stimulated echo encoding in the muscle of rabbit shank
Fast low‐angle shot diffusion tensor imaging with stimulated echo encoding in the muscle of rabbit shank
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兔小腿肌肉受激回波编码的快速低角度拍摄扩散张量成像
DOI：
10.1002/nbm.3046
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发表时间：
2014
影响因子：
2.9
通讯作者：
Reichenbach JR
中科院分区：
文献类型：
--
作者：
Hiepe P;Herrmann KH;Güllmar D;Siebert T;Blickhan R;Hahn K;Reichenbach JR
在过去，基于自旋回波（SE）回波平面成像（EPI）的扩散张量成像（DTI）已被广泛用于研究体内骨骼肌的纤维结构。然而，当测量小动物中的受限扩散时，该序列具有几个缺点，例如其对与敏感性相关的失真的敏感性和相对较短的适用扩散时间。为了解决这些局限性，在目前的工作中，实施了一种刺激回波采集模式（STEAM）MRI技术，结合快速低角度拍摄（FLASH）读出（turbo-STEAM MRI），并针对骨骼肌中的DTI进行了调整。使用受激回波进行信号准备可以延长有效扩散时间，从而检测细胞内距离高达100 µm的肌肉组织内的受限扩散。此外，它具有减少的惩罚fastT 2肌肉信号衰减，但在50%的信号损失的代价相比，SE准备。Turbo‐STEAM MRI有助于骨骼肌的高分辨率DTI，而不会引入与敏感性相关的失真。为了证明其适用性，我们在人体全身3 T扫描仪上进行了兔蛋白活体测量。提取小腿肌肉的DTI参数，包括表观扩散系数、分数各向异性、特征值和特征向量。用特征向量计算结构参数的映射，如平面指数和最大特征向量的极坐标θ和θ。比较了三块肌肉的这些参数，θ和θ在三块肌肉之间显示出明显的差异，反映了底层纤维结构的不同羽状角。纤维束成像用于观察和分析骨骼羽状肌的结构。跟踪参数的优化和T2加权图像用于改进的肌肉边界检测使得能够确定额外的参数，例如平均纤维长度。所提供的结果支持turbo‐STEAM MRI作为定量DTI分析和骨骼肌纤维束成像的有前途方法的适用性。版权所有© 2013约翰威利父子有限公司.
In the past, spin‐echo (SE) echo planar imaging(EPI)‐based diffusion tensor imaging (DTI) has been widely used to study the fiber structure of skeletal musclesin vivo. However, this sequence has several shortcomings when measuring restricted diffusion in small animals, such as its sensitivity to susceptibility‐related distortions and a relatively short applicable diffusion time. To address these limitations, in the current work, a stimulated echo acquisition mode (STEAM) MRI technique, in combination with fast low‐angle shot (FLASH) readout (turbo‐STEAM MRI), was implemented and adjusted for DTI in skeletal muscles. Signal preparation using stimulated echoes enables longer effective diffusion times, and thus the detection of restricted diffusion within muscular tissue with intracellular distances up to 100 µm. Furthermore, it has a reduced penalty for fastT2muscle signal decay, but at the expense of 50% signal loss compared with a SE preparation. Turbo‐STEAM MRI facilitates high‐resolution DTI of skeletal muscle without introducing susceptibility‐related distortions. To demonstrate its applicability, we carried out rabbitin vivomeasurements on a human whole‐body 3 T scanner. DTI parameters of the shank muscles were extracted, including the apparent diffusion coefficient, fractional anisotropy, eigenvalues and eigenvectors. Eigenvectors were used to calculate maps of structural parameters, such as the planar index and the polar coordinatesθandϕof the largest eigenvector. These parameters were compared between three muscles.θandϕshowed clear differences between the three muscles, reflecting different pennation angles of the underlying fiber structures. Fiber tractography was performed to visualize and analyze the architecture of skeletal pennate muscles. Optimization of tracking parameters and utilization ofT2‐weighted images for improved muscle boundary detection enabled the determination of additional parameters, such as the mean fiber length. The presented results support the applicability of turbo‐STEAM MRI as a promising method for quantitative DTI analysis and fiber tractography in skeletal muscles. Copyright © 2013 John Wiley & Sons, Ltd.
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影响因子：
3.3
作者：
Lansdown, Drew A.;Ding, Zhaohua;Damon, Bruce M.
通讯作者：
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DOI：
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发表时间：
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影响因子：
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影响因子：
3.3
作者：
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通讯作者：
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Vergleich von Long-Axis- 和 Short-Axis-PROPELLER-EPI for die spreadsgewichtete Magnetresonanztomography
DOI：
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发表时间：
2011
期刊：
影响因子：
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作者：
M. Rossbach;T. Jochimsen;K. Herrmann;C. Ros;D. Güllmar;J. Reichenbach
通讯作者：
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影响因子：
5.9
作者：
Budzik, J. F.;Le Thuc, V.;Cotten, A.
通讯作者：
Cotten, A.