Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment.
Perivascular pumping in the mouse brain: Improved boundary conditions reconcile theory, simulation, and experiment.
复制标题
DOI：
10.1016/j.jtbi.2022.111103
复制
发表时间：
2022-06-07
影响因子：
2
通讯作者：
Kelley, Douglas H.
中科院分区：
文献类型：
--
作者：
Ladron-de-Guevara, Antonio;Shang, Jessica K.;Nedergaard, Maiken;Kelley, Douglas H.
脑脊液（CSF）流经脑动脉周围的血管周围空间（PVS）。揭示驱动这种流动的机制可以增进对脑废物运输的理解，并深入了解阿尔茨海默病和中风等疾病。小鼠表面PVS中脑脊液的体内速度测量已被用来证明血流主要是由动脉壁的脉动运动（血管周围泵送）驱动的。然而，流体动力学理论和模拟预测，血管周围泵送产生的流动与体内观察完全不同，特别是在流动振荡的相位和相对振幅方面。我们表明，使用在小鼠中测量的阻力和柔量值而不是使用周期性边界，将理论和模拟流耦合到更现实的最终边界条件，会导致速度在相位和相对振荡幅度上更接近地匹配观察结果，同时保持平均流速的现有一致性。理论、模拟和体内测量之间的定量一致性进一步支持了血管周围泵送是生理条件下重要的脑脊液驱动因素的观点。
Cerebrospinal fluid (CSF) flows through the perivascular spaces (PVSs) surrounding cerebral arteries. Revealing the mechanisms driving that flow could bring improved understanding of brain waste transport and insights for disorders including Alzheimer’s disease and stroke. In vivo velocity measurements of CSF in surface PVSs in mice have been used to argue that flow is driven primarily by the pulsatile motion of artery walls — perivascular pumping. However, fluid dynamics theory and simulation have predicted that perivascular pumping produces flows differing from in vivo observations starkly, particularly in the phase and relative amplitude of flow oscillation. We show that coupling theoretical and simulated flows to more realistic end boundary conditions, using resistance and compliance values measured in mice instead of using periodic boundaries, results in velocities that match observations more closely in phase and relative amplitude of oscillation, while preserving the existing agreement in mean flow speed. This quantitative agreement among theory, simulation, and in vivo measurement further supports the idea that perivascular pumping is an important CSF driver in physiological conditions.
登录
查看更多内容
DOI：
10.1177/0271678x17737984
发表时间：
2018-04
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Bedussi B;Almasian M;de Vos J;VanBavel E;Bakker EN
通讯作者：
Bakker EN
DOI：
10.1093/brain/awaa443
发表时间：
2021-04-12
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Eide, Per Kristian;Vinje, Vegard;Ringstad, Geir
通讯作者：
Ringstad, Geir
DOI：
10.1177/0271678x21996175
发表时间：
2021-09
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
Bèchet NB;Shanbhag NC;Lundgaard I
通讯作者：
Lundgaard I
影响因子：
17.1
作者：
Iliff JJ;Wang M;Liao Y;Plogg BA;Peng W;Gundersen GA;Benveniste H;Vates GE;Deane R;Goldman SA;Nagelhus EA;Nedergaard M
通讯作者：
Nedergaard M
影响因子：
12.4
作者：
Hadaczek, P;Yamashita, Y;Bankiewicz, K
通讯作者：
Bankiewicz, K