Association of SOX2 and Nestin DNA amplification and protein expression with clinical features and overall survival in non-small cell lung cancer: A systematic review and meta-analysis.
Association of SOX2 and Nestin DNA amplification and protein expression with clinical features and overall survival in non-small cell lung cancer: A systematic review and meta-analysis.
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SOX2 和 Nestin DNA 扩增和蛋白表达与非小细胞肺癌临床特征和总生存率的关联：系统评价和荟萃分析。
DOI：
10.18632/oncotarget.9145
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发表时间：
2016-06-07
期刊：
影响因子：
--
通讯作者：
Meng X
中科院分区：
文献类型：
--
作者：
Li Q;Liu F;Zhang Y;Fu L;Wang C;Chen X;Guan S;Meng X
目前，非小细胞肺癌（non-small cell lung cancer，NSCLC）的预后较差。随着肿瘤生物学研究的进展，一些基因被研究用于预测非小细胞肺癌的预后，如肿瘤干细胞标志物SRY（sex determining region Y）-box 2（SOX 2）和Nestin。近年来，有一系列研究探讨了SOX 2和Nestin与NSCLC临床参数和预后的关系，但结果并不一致。在本研究中，我们进行了系统的回顾和荟萃分析，以总结相关性。使用4个英文数据库（PubMed、ISI web of science、Embase和奥维德）检索最后日期为2015年11月10日的相关研究。合并分析通过DNA扩增和蛋白质表达分层。合并OR或HR用于评估关联的强度。最后，根据纳入和排除标准，我们纳入了19篇关于SOX 2的文章和6篇关于Nestin的文章。汇总分析显示，SOX 2 DNA扩增与NSCLC的临床特征、性别、吸烟状况、鳞状细胞癌（SCC）组织学和分化之间存在显著相关性。SOX 2蛋白表达与临床参数、吸烟状况和SCC组织学之间也存在显著相关性。Nestin蛋白的表达与淋巴结转移和临床分期有关。同时，我们发现高/阳性SOX 2改变，无论是DNA扩增还是蛋白表达，都有利于NSCLC的总生存期（OS）。相反，高/阳性Nestin蛋白表达在OS中是差的。
Up to now, the prognosis of non-small cell lung cancer (NSCLC) is poor. With progress of cancer biology, a number of genes have been investigated for predicting prognosis of NSCLC, such as cancer stem cell markers SRY (sex determining region Y)-box 2 (SOX2) and Nestin. Recently, a series of studies have been performed to examine the associations of SOX2 and Nestin with clinical parameters and prognosis in NSCLC, however, the results were not consistent. In the present study, we conducted a systematic review and meta-analysis to summarize the associations. Four English databases (PubMed, ISI web of science, Embase, and Ovid) were used to search the relevant studies with the last date of November 10, 2015. The pooling analyses were stratified by DNA amplification and protein expression. The pooling ORs or HRs were used to assess the strength of the associations. Finally, we included 19 articles for SOX2 and six articles for Nestin according to the inclusion and exclusion criteria. The pooling analyses revealed that there were significant associations between SOX2 DNA amplification and clinical features of NSCLC, gender, smoking status, squamous cell cancer (SCC) histology, and differentiations. And significant associations were also identified between SOX2 protein expression and clinical parameters, smoking status and SCC histology. For Nestin, its protein expression was correlated with lymph node metastasis and stage. Simultaneously, we found that high/positive SOX2 alterations, either DNA amplification or protein expression, were favorable for overall survival (OS) in NSCLC. On the contrary, high/positive Nestin protein expression was poor for OS.
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影响因子：
5.2
作者：
Iijima Y;Seike M;Noro R;Ibi T;Takeuchi S;Mikami I;Koizumi K;Usuda J;Gemma A
通讯作者：
Gemma A
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
30.8
作者：
Bass, Adam J.;Watanabe, Hideo;Mermel, Craig H.;Yu, Soyoung;Perner, Sven;Verhaak, Roel G.;Kim, So Young;Wardwell, Leslie;Tamayo, Pablo;Gat-Viks, Irit;Ramos, Alex H.;Woo, Michele S.;Weir, Barbara A.;Getz, Gad;Beroukhim, Rameen;O'Kelly, Michael;Dutt, Amit;Rozenblatt-Rosen, Orit;Dziunycz, Piotr;Komisarof, Justin;Chirieac, Lucian R.;LaFargue, Christopher J.;Scheble, Veit;Wilbertz, Theresia;Ma, Changqing;Rao, Shilpa;Nakagawa, Hiroshi;Stairs, Douglas B.;Lin, Lin;Giordano, Thomas J.;Wagner, Patrick;Minna, John D.;Gazdar, Adi F.;Zhu, Chang Qi;Brose, Marcia S.;Cecconello, Ivan;Ribeiro, Ulysses, Jr.;Marie, Suely K.;Dahl, Olav;Shivdasani, Ramesh A.;Tsao, Ming-Sound;Rubin, Mark A.;Wong, Kwok K.;Regev, Aviv;Hahn, William C.;Beer, David G.;Rustgi, Anil K.;Meyerson, Matthew
通讯作者：
Meyerson, Matthew
影响因子：
3.7
作者：
Freier, Koija;Knoepfle, Karl;Radwirnmer, Bernhard
通讯作者：
Radwirnmer, Bernhard
影响因子：
10.8
作者：
Chiou, Guang-Yuh;Cherng, Jong-Yuh;Chiou, Shih-Hwa
通讯作者：
Chiou, Shih-Hwa