Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis.
Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis.
复制标题
DOI：
10.1038/s41467-023-37732-1
复制
发表时间：
2023-04-20
影响因子：
16.6
通讯作者：
McCarthy, Alex J
中科院分区：
文献类型：
--
作者：
Catton, Erin A;Bonsor, Daniel A;Herrera, Carolina;Stalhammar-Carlemalm, Margaretha;Lyndin, Mykola;Turner, Claire E;Soden, Jo;van Strijp, Jos A G;Singer, Bernhard B;van Sorge, Nina M;Lindahl, Gunnar;McCarthy, Alex J
生命危害生命的细菌感染在分娩后，被称为脓毒症，导致了经典的流行病，并且仍然是全球健康问题。在流行病学上，细菌R28蛋白与植物爆发相关，特别针对人体受体CeCAM1。这种相互作用会触发植物败血症的发展，包括对宫颈细胞的广告，抑制上皮伤口修复和颠覆先天性免疫反应的结构分析。 - CEACAM1的末端结构域。分子对病史中最重要的传染病之一的发病机理的见解。
Catton等人的分娩后，分娩后的链球菌感染。
Life-threatening bacterial infections in women after childbirth, known as puerperal sepsis, resulted in classical epidemics and remain a global health problem. While outbreaks of puerperal sepsis have been ascribed to Streptococcus pyogenes, little is known about disease mechanisms. Here, we show that the bacterial R28 protein, which is epidemiologically associated with outbreaks of puerperal sepsis, specifically targets the human receptor CEACAM1. This interaction triggers events that would favor the development of puerperal sepsis, including adhesion to cervical cells, suppression of epithelial wound repair and subversion of innate immune responses. High-resolution structural analysis showed that an R28 domain with IgI3-like fold binds to the N-terminal domain of CEACAM1. Together, these findings demonstrate that a single adhesin-receptor interaction can drive the pathogenesis of bacterial sepsis and provide molecular insights into the pathogenesis of one of the most important infectious diseases in medical history. Infection with Streptococcus pyogenes after childbirth can have life threatening consequences. Here, Catton et al. show that the epidemiologically associated bacterial R28 protein targets the human CEACAM1 receptor to facilitate the pathogenesis of bacterial sepsis.
登录
查看更多内容
影响因子：
2.7
作者：
Fox JM;Wiggins RC;Moore JWJ;Brewer C;Hunter B;Andrew AC;Martin F
通讯作者：
Martin F
影响因子：
15.3
作者：
Hu, QX;Frank, I;Williams, V;Santos, JJ;Watts, P;Griffin, GE;Moore, JR;Pope, M;Shattock, RJ
通讯作者：
Shattock, RJ
影响因子：
11.4
作者：
Conners, Rebecca;Hill, Darryl J.;Borodina, Elena;Agnew, Christopher;Daniell, Sarah J.;Burton, Nicholas M.;Sessions, Richard B.;Clarke, Anthony R.;Catto, Lucy E.;Lammie, Donna;Wess, Timothy;Brady, R. Leo;Virji, Mumtaz
通讯作者：
Virji, Mumtaz
影响因子：
4.2
作者：
Sitkiewicz I;Green NM;Guo N;Mereghetti L;Musser JM
通讯作者：
Musser JM