Control of abnormal synchronization in neurological disorders.
Control of abnormal synchronization in neurological disorders.
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DOI：
10.3389/fneur.2014.00268
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发表时间：
2014
影响因子：
3.4
通讯作者：
Tass PA
中科院分区：
文献类型：
--
作者：
Popovych OV;Tass PA
在神经系统中，同步过程扮演着重要的角色，例如，在信息处理和运动控制方面。然而，病理性的过度同步可能会严重损害大脑功能，是几种神经疾病的标志。这篇重点讨论的问题是如何通过有创性和非侵入性脑刺激来具体抵消异常神经元同步性的问题，例如，通过治疗帕金森氏病的脑深部刺激，或通过治疗耳鸣的声刺激。在协调重置(CR)神经调节的例子中，我们说明了对复杂系统动力学的洞察如何有助于成功的基于模型的方法，这些方法使用协同学、非线性动力学和统计物理的方法来开发大脑功能和突触连接的正常化的新疗法。基于脉冲时序可塑性(STDP)诱导的神经元群体的内在多稳定性，CR神经调制利用突触连接和神经元网络动力学之间的相互依赖，通过神经元活动的去同步化来恢复更多的生理连接模式。其目标就是通过刺激将神经元群体从异常耦合和同步状态转变为具有正常突触连接的去同步状态，从而显著延长刺激停止的时间，从而获得长期的治疗效果。
In the nervous system, synchronization processes play an important role, e.g., in the context of information processing and motor control. However, pathological, excessive synchronization may strongly impair brain function and is a hallmark of several neurological disorders. This focused review addresses the question of how an abnormal neuronal synchronization can specifically be counteracted by invasive and non-invasive brain stimulation as, for instance, by deep brain stimulation for the treatment of Parkinson’s disease, or by acoustic stimulation for the treatment of tinnitus. On the example of coordinated reset (CR) neuromodulation, we illustrate how insights into the dynamics of complex systems contribute to successful model-based approaches, which use methods from synergetics, non-linear dynamics, and statistical physics, for the development of novel therapies for normalization of brain function and synaptic connectivity. Based on the intrinsic multistability of the neuronal populations induced by spike timing-dependent plasticity (STDP), CR neuromodulation utilizes the mutual interdependence between synaptic connectivity and dynamics of the neuronal networks in order to restore more physiological patterns of connectivity via desynchronization of neuronal activity. The very goal is to shift the neuronal population by stimulation from an abnormally coupled and synchronized state to a desynchronized regime with normalized synaptic connectivity, which significantly outlasts the stimulation cessation, so that long-lasting therapeutic effects can be achieved.
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影响因子：
4.4
作者：
CANDY, JM;PERRY, RH;TOMLINSON, BE
通讯作者：
TOMLINSON, BE
影响因子：
8.6
作者：
Benabid, AL;Benazzous, A;Pollak, P
通讯作者：
Pollak, P
影响因子：
1.9
作者：
Danzl, Per;Hespanha, Joao;Moehlis, Jeff
通讯作者：
Moehlis, Jeff
影响因子：
5.3
作者：
Brown, P;Mazzone, P;Di Lazzaro, V
通讯作者：
Di Lazzaro, V
影响因子：
8.6
作者：
Adamchic, Ilya;Hauptmann, Christian;Barnikol, Utako Brigit;Pawelczyk, Norbert;Popovych, Oleksandr;Barnikol, Thomas Theo;Silchenko, Alexander;Volkmann, Jens;Deuschl, Guenter;Meissner, Wassilios G.;Maarouf, Mohammad;Sturm, Volker;Freund, Hans-Joachim;Tass, Peter Alexander
通讯作者：
Tass, Peter Alexander