Gestational diabetes as a risk factor for pancreatic cancer: a prospective cohort study.
Gestational diabetes as a risk factor for pancreatic cancer: a prospective cohort study.
复制标题
DOI：
10.1186/1741-7015-5-25
复制
发表时间：
2007-08-16
期刊：
影响因子：
9.3
通讯作者：
Harlap S
中科院分区：
文献类型：
--
作者：
Perrin MC;Terry MB;Kleinhaus K;Deutsch L;Yanetz R;Tiram E;Calderon R;Friedlander Y;Paltiel O;Harlap S
众所周知，糖尿病与胰腺癌有关，尽管关于它是疾病的原因还是后果存在一些争论。我们调查了37926名以色列妇女的胰腺癌发病率，随访28-40年，这些妇女在1964-1976年在耶路撒冷分娩时收集了糖尿病信息。在随访期间，以色列癌症登记处确定了54例胰腺癌。我们使用考克斯比例风险模型来调整基线年龄，并探索其他风险因素的影响，包括种族，先兆子痫，出生顺序和后代出生体重。我们没有观察到胰岛素依赖型糖尿病妇女发生胰腺癌的病例，但是，妊娠期糖尿病妇女发生了5例胰腺癌。妊娠期糖尿病的记录和胰腺癌的诊断之间的间隔为14-35年。有妊娠期糖尿病史的妇女患胰腺癌的相对危险度为7.1（95%可信区间为2.8-18.0）。我们的结论是，妊娠期糖尿病是密切相关的风险，胰腺癌的妇女在这一人群中，妊娠期糖尿病可以提前许多年的癌症诊断。
Diabetes is known to be associated with cancer of the pancreas, though there is some debate as to whether it is a cause or a consequence of the disease. We investigated the incidence of pancreatic cancer in a cohort of 37926 Israeli women followed for 28–40 years for whom information on diabetes had been collected at the time they gave birth, in 1964–1976, in Jerusalem. There were 54 cases of pancreatic cancer ascertained from the Israel Cancer Registry during follow-up. We used Cox proportional hazards models to adjust for age at baseline and explore effects of other risk factors, including ethnic groups, preeclampsia, birth order and birth weight of offspring. We observed no cases of pancreatic cancer in the women with insulin dependent diabetes; however, there were five cases in the women with gestational diabetes. The interval between the record of diabetes in pregnancy and the diagnosis of pancreatic cancer ranged from 14–35 years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1 (95% confidence interval, 2.8–18.0). We conclude that gestational diabetes is strongly related to the risk of cancer of the pancreas in women in this population, and that gestational diabetes can precede cancer diagnosis by many years.
登录
查看更多内容
影响因子：
7.7
作者：
DOOLEY, SL;METZGER, BE;CHO, NH
通讯作者：
CHO, NH
影响因子：
12.7
作者：
Thorpe, LE;Berger, D;Frieden, TR
通讯作者：
Frieden, TR
影响因子：
16.2
作者：
Dabelea, D;Snell-Bergeon, JK;McDuffie, RS
通讯作者：
McDuffie, RS
影响因子：
5.8
作者：
SUIKKARI, AM;KOIVISTO, VA;SEPPALA, M
通讯作者：
SEPPALA, M
DOI：
10.1016/s0002-9378(11)90675-9
发表时间：
1990-07-01
影响因子：
9.8
作者：
GREEN, JR;PAWSON, IG;KRETCHMER, N
通讯作者：
KRETCHMER, N