Preservation of acute pain and efferent functions following intrathecal resiniferatoxin-induced analgesia in rats.
Preservation of acute pain and efferent functions following intrathecal resiniferatoxin-induced analgesia in rats.
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DOI：
10.1016/j.jpain.2011.03.005
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Premkumar LS
中科院分区：
文献类型：
--
作者：
Bishnoi M;Bosgraaf CA;Premkumar LS
树脂毒素（RTX）是TRPV 1的强效激动剂，具有独特的性质，可用于治疗某些形式的疼痛。在本研究中，全身腹膜内（i. p.）RTX的施用导致急性热疼痛敏感性的显著降低，而局部鞘内（i. t.）给药对急性热痛敏感性没有影响。ip和i.t. RTX的施用防止TRPV 1诱导的伤害反应行为和炎性热超敏反应。通过i. p.或i.t.，机械灵敏度没有变化。使用RTX。在脊髓背角（L4-L 6），TRPV 1和P物质的免疫反应性被取消，i. p.和i.t.使用RTX。在背根神经节（DRG）中，TRPV 1免疫反应性在i. p.给药后减弱，但在i.t.给药后不受影响。使用RTX。腹膜内给药后，脊髓和外周组织中的基础和诱发CGRP释放均减少。然而，在i.t.给药后，脊髓（L4-L 6）中的基础和诱发CGRP释放减少，但外周组织中不受影响。ip和i.t. RTX给药使体温急剧下降，但这种作用随着时间的推移而逆转。靶向脊髓中表达TRPV 1的神经末梢可以选择性地消除炎性热超敏反应而不影响急性热敏感性，并且可以保留外周神经末梢处DRG神经元的传出功能。I.T. RTX给药可被视为治疗某些慢性和衰弱性疼痛疾病的策略。
Resiniferatoxin (RTX) is a potent agonist of TRPV1, which possesses unique properties that can be utilized to treat certain modalities of pain. In the present study, systemic intraperitoneal (i.p.) administration of RTX resulted in a significant decrease in acute thermal pain sensitivity, whereas localized intrathecal (i.t.) administration had no effect on acute thermal pain sensitivity. Both i.p. and i.t. administration of RTX prevented TRPV1-induced nocifensive behavior and inflammatory thermal hypersensitivity. There were no alterations in mechanical sensitivity either by i.p. of i.t. administration of RTX. In spinal dorsal horn (L4-L6), TRPV1 and substance P immunoreactivity were abolished following i.p. and i.t. administration of RTX. In dorsal root ganglia (DRG), TRPV1 immunoreactivity was diminished following i.p. administration, but was unaffected following i.t. administration of RTX. Following i.p. administration, basal and evoked CGRP release was reduced both in the spinal cord and peripheral tissues. However, following i.t. administration, basal and evoked CGRP release was reduced in spinal cord (L4-L6), but was unaffected in peripheral tissues. Both i.p. and i.t. RTX administration lowered the body temperature acutely, but this effect reversed with time. Targeting TRPV1 expressing nerve terminals at the spinal cord can selectively abolish inflammatory thermal hypersensitivity without affecting acute thermal sensitivity and can preserve the efferent functions of DRG neurons at the peripheral nerve terminals. I.t. administration of RTX can be considered as a strategy for treating certain chronic and debilitating pain conditions.
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影响因子：
4.7
作者：
Massa, F;Sibaev, A;Lutz, B
通讯作者：
Lutz, B
DOI：
10.1016/0024-3205(69)90283-5
发表时间：
1969-01-01
期刊：
LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY
影响因子：
--
作者：
BRETAG, AH
通讯作者：
BRETAG, AH
影响因子：
3.3
作者：
Neubert JK;Mannes AJ;Karai LJ;Jenkins AC;Zawatski L;Abu-Asab M;Iadarola MJ
通讯作者：
Iadarola MJ
影响因子：
7.4
作者：
Bates BD;Mitchell K;Keller JM;Chan CC;Swaim WD;Yaskovich R;Mannes AJ;Iadarola MJ
通讯作者：
Iadarola MJ
DOI：
10.1016/1056-8719(94)90087-6
发表时间：
1994-12-01
影响因子：
1.9
作者：
MESTRE, C;PELISSIER, T;ESCHALIER, A
通讯作者：
ESCHALIER, A