α-Methylacyl-CoA racemase (AMACR) serves as a prognostic biomarker for the early recurrence/metastasis of HCC.
α-Methylacyl-CoA racemase (AMACR) serves as a prognostic biomarker for the early recurrence/metastasis of HCC.
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DOI：
10.1136/jclinpath-2014-202378
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发表时间：
2014-11
影响因子：
3.4
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Xu B;Cai Z;Zeng Y;Chen L;Du X;Huang A;Liu X;Liu J
肝细胞癌（HCC）是世界范围内最常见的恶性肿瘤之一，迄今仍缺乏有效的预后生物标志物。先前基于itraq的定量蛋白质组学研究（iTRAQ-2DLC-MS/MS）结果表明，α-甲基酰基辅酶a消消酶（AMACR）可能是肝细胞癌（HCC）早期复发/转移的预后生物标志物。这里进行了一项大规模队列临床研究，以评估其预后潜力。来自患者的HCC样本（n=158）用于构建组织芯片。免疫组化染色检测AMACR的表达水平。为了评估AMACR在HCC早期复发/转移中的预后潜力，我们进行了一项大规模队列临床研究，研究AMACR的表达与一些主要临床参数之间的关系。α-胎蛋白、肿瘤数量、局部淋巴结播散、肿瘤囊、门静脉肿瘤血栓形成等重要临床参数均与AMACR的低表达有显著相关性。AMACR的表达是影响HCC患者生存的独立因素。低表达组的中位生存时间为17个月，而高表达组的中位生存时间为45个月。本研究表明，AMACR可能是预测肝切除术后早期HCC复发/转移的潜在预后指标。
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, and it is still lacking effective prognostic biomarkers so far. Previous results of the iTRAQ-based quantitative proteomics study (iTRAQ-2DLC-MS/MS) have shown that α-methylacyl-CoA racemase (AMACR) might be a promising prognostic biomarker for the early recurrence/metastasis of hepatocellular carcinoma (HCC). Here a large-scale cohort clinical study was performed to evaluate its prognostic potential. HCC samples from patients (n=158) were used for the construction of tissue microarray. The expression level of AMACR was determined by immunohistochemical staining. A large-scale cohort clinical study between the expression of AMACR and some major clinical parameter has been performed to assess the prognostic potential of AMACR for the early recurrence/metastasis of HCC. Some important clinical parameters such as α-fetoprotein, tumour numbers, dissemination to regional lymph nodes, tumour capsule and portal vein tumour thrombosis are significantly associated with the low expression of AMACR. The expression of AMACR was an independent factor for the survival of patients with HCC. The median survival time was 17 months in the low-expression group compared with 45 months in the high-expression group. This study reveals that the AMACR might be a potential prognostic marker for predicting early recurrence/metastasis of HCC after hepatectomy.
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影响因子：
5.1
作者：
Chen, Wan-qing;Zeng, Hong-mei;He, Jie
通讯作者：
He, Jie
影响因子：
3.8
作者：
Rubin, MA;Bismar, TA;Johansson, JE
通讯作者：
Johansson, JE
影响因子：
6.2
作者：
Liau, KH;Ruo, L;DeMatteo, RP
通讯作者：
DeMatteo, RP
影响因子：
6
作者：
Rubin, MA;Zerkowski, MP;Rimm, DL
通讯作者：
Rimm, DL
影响因子：
6.4
作者：
Sekine, Shigeki;Ogawa, Reiko;Kanai, Yae
通讯作者：
Kanai, Yae