Sphingosine analog AAL-R promotes activation of LCMV-infected dendritic cells.
Sphingosine analog AAL-R promotes activation of LCMV-infected dendritic cells.
复制标题
鞘氨醇类似物 AAL-R 促进 LCMV 感染的树突状细胞的激活。
DOI：
10.1089/vim.2013.0096
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发表时间：
2014
期刊：
影响因子：
2.2
通讯作者：
Hahm,Bumsuk
中科院分区：
文献类型：
--
作者：
Seo,Young-Jin;Hahm,Bumsuk
Sphingosine analogs display diverse immunoregulatory activities with curative potential in autoimmune diseases and viral infections. Recently, the sphingosine analog AAL-R was shown to increase DC activation upon TLR7 stimulation. Here, we investigated the effect of AAL-R on activation of dendritic cells (DCs) infected by lymphocytic choriomeningitis virus (LCMV). Concomitant treatment of LCMV-infected DCs with AAL-R enhanced DC maturation and DC ability to stimulate and expand antiviral CD8+T cells. Importantly, AAL-R's stimulatory activity was abrogated in type I interferon (IFN) receptor-deficient DCs following LCMV infection. In support of this observation, AAL-R increased type I IFN production from DCs infected with LCMV. Taken together, the sphingosine analog could directly act on DCs to promote defensive host DC responses to the viral invasion via type I IFN signaling.
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