The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.
The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians.
复制标题
Klotho的功能性“ KL-VS”变体与5028英国高加索人的2型糖尿病无关。
DOI：
10.1186/1471-2350-7-51
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发表时间：
2006-06-05
影响因子：
--
通讯作者：
Frayling TM
中科院分区：
文献类型：
--
作者：
Freathy RM;Weedon MN;Melzer D;Shields B;Hitman GA;Walker M;McCarthy MI;Hattersley AT;Frayling TM
Klotho has an important role in insulin signalling and the development of ageing-like phenotypes in mice. The common functional "KL-VS" variant in the KLOTHO (KL) gene is associated with longevity in humans but its role in type 2 diabetes is not known. We performed a large case-control and family-based study to test the hypothesis that KL-VS is associated with type 2 diabetes in a UK Caucasian population. We genotyped 1793 cases, 1619 controls and 1616 subjects from 509 families for the single nucleotide polymorphism (SNP) F352V (rs9536314) that defines the KL-VS variant. Allele and genotype frequencies were compared between cases and controls. Family-based analysis was used to test for over- or under-transmission of V352 to affected offspring. Despite good power to detect odds ratios of 1.2, there were no significant associations between alleles or genotypes and type 2 diabetes (V352 allele: odds ratio = 0.96 (0.84–1.09)). Additional analysis of quantitative trait data in 1177 healthy control subjects showed no association of the variant with fasting insulin, glucose, triglycerides, HDL- or LDL-cholesterol (all P > 0.05). However, the HDL-cholesterol levels observed across the genotype groups showed a similar, but non-significant, pattern to previously reported data. This is the first large-scale study to examine the association between common functional variation in KL and type 2 diabetes risk. We have found no evidence that the functional KL-VS variant is a risk factor for type 2 diabetes in a large UK Caucasian case-control and family-based study.
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Klotho的功能性“ KL-VS”变体与5028英国高加索人的2型糖尿病无关。
影响因子：
--
作者：
Freathy RM;Weedon MN;Melzer D;Shields B;Hitman GA;Walker M;McCarthy MI;Hattersley AT;Frayling TM
通讯作者：
Frayling TM
影响因子：
7.7
作者：
Frayling, TM;Walker, M;Hattersley, AT
通讯作者：
Hattersley, AT
影响因子：
2.1
作者：
Blangero, J;Williams, JT;Almasy, L
通讯作者：
Almasy, L
影响因子：
7.7
作者：
Weedon, MN;Owen, KR;Frayling, TM
通讯作者：
Frayling, TM
影响因子：
2.8
作者：
Knight, B;Shields, BM;Hattersley, AT
通讯作者：
Hattersley, AT