Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type.
Endoscopic resection is a suitable initial treatment strategy for oxyntic gland adenoma or gastric adenocarcinoma of the fundic gland type.
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DOI：
10.1038/s41598-021-86893-w
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发表时间：
2021-04-01
影响因子：
4.6
通讯作者：
Okada H
中科院分区：
文献类型：
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作者：
Iwamuro M;Kusumoto C;Nakagawa M;Kobayashi S;Yoshioka M;Inaba T;Toyokawa T;Hori S;Tanaka S;Matsueda K;Tanaka T;Okada H
本研究的目的是揭示胃泌酸腺腺瘤和胃底腺型胃腺癌（GA-FG）的组织学特征。我们回顾性研究了116例患者的126个泌酸腺腺瘤和/或GA-FG病灶的组织学特征。泌酸腺腺瘤和GA-FG的患病率大致相等。大多数病变通过使用透热圈套器（EMR，n = 42）或内镜粘膜下剥离术（ESD，n = 72）的内镜粘膜切除术切除。组织学上，没有浸润到固有肌层或更深的病变，淋巴管浸润率为1.6%。在ESD和EMR标本中，没有垂直边缘阳性的病变。在8例深度（≥ 500 μm）粘膜下浸润的GA-FG患者中，6例仅接受了内窥镜切除术，没有记录到复发。在14.5个月的中位随访期内，没有患者死于该疾病。总之，所有病变均局限于粘膜或粘膜下层，垂直边缘阴性。仅1.6%的患者存在血管侵犯。因此，我们相信内视镜切除术是一个合适的初始治疗方法，对泌酸腺腺瘤和GA-FG。
The aim of this study was to reveal the histological features of oxyntic gland adenomas and gastric adenocarcinoma of the fundic-gland type (GA-FG). We retrospectively examined the histological features of 126 lesions of oxyntic gland adenoma and/or GA-FG in 116 patients. The prevalence of oxyntic gland adenomas and GA-FG was approximately equal. The majority of the lesions were resected by endoscopic mucosal resection using a diathermic snare (EMR, n = 42) or endoscopic submucosal dissection (ESD, n = 72). Histologically, there were no lesions with invasion at the level of the muscularis propria or deeper, and lymphovascular invasion was present in 1.6%. Of the ESD and EMR specimens, there were no lesions that were positive for vertical margins. Among the eight GA-FG patients with deep (≥ 500 μm) submucosal invasion, six were treated with endoscopic resection alone, and no recurrence was documented. No patients died of the disease during the median follow-up period of 14.5 months. In conclusion, all lesions were confined to the mucosa or submucosa and were negative for vertical margins. Lymphovascular invasion was present in only 1.6% of the patients. Thus, we believe that endoscopic resection is a suitable initial treatment method for oxyntic gland adenoma and GA-FG.
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影响因子：
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作者：
Park ES;Kim YE;Park CK;Yao T;Kushima R;Kim KM
通讯作者：
Kim KM
影响因子：
5.6
作者：
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影响因子：
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