Emerging approaches to male contraception.
Emerging approaches to male contraception.
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DOI：
10.1016/j.fertnstert.2021.03.047
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发表时间：
2021-06
影响因子：
6.7
通讯作者：
Amory JK
中科院分区：
文献类型：
--
作者：
Thirumalai A;Amory JK
尽管男性对避孕很感兴趣，但有效的男性避孕方法仅限于输精管结扎术和避孕套。最近，男性避孕研究取得了一些有希望的进展。这篇评论将更新读者对激素和非激素的男性避孕方法的最新研究。男性避孕的激素方法受到不良反应、需要注射或植入的制剂、5-10%的无反应率以及对用户可接受性的理解不足的阻碍。在过去的几年里，研究集中在新的，口服生物可利用的雄激素，如二甲雄龙十一酸酯和11β-甲基-19-去甲睾酮。此外，外用睾酮凝胶与含有Nestorone（一种强效的睾酮）的凝胶组合，最近在临床试验中显示出了希望。同时，在非激素男性避孕药的几种方法中取得了显著的临床前进展，包括抑制精子运动性的化合物如EPPIN，抑制视黄酸结合或生物合成的化合物，以及输精管阻塞的可逆方法。这两个领域的研究必须继续取得进展，以便有各种避孕方法供夫妇选择。其中一些方法有望很快达到临床实用，大大改善夫妇的避孕选择。最近，男性避孕研究取得了一些有希望的进展。其中一些方法有望很快达到临床实用，大大改善夫妇的避孕选择。
Despite significant interest in contraception by men, effective methods of male contraception are limited to vasectomy and condoms. Recently, there have been several promising advances in male contraceptive research. This review will update readers on recent research in both hormonal and non-hormonal approaches to male contraception. Hormonal approaches to male contraception have been stymied by adverse effects, formulations requiring injections or implants, a 5-10% non-response rate, as well as poor understanding of user acceptability. In the last several years, research has focused on novel, orally bio-available androgens such as dimethandrolone undecanoate and 11β-methyl-19-nor-testosterone. Additionally combinations of a topical testosterone gel combined with a gel containing Nestorone, a potent progestin, have shown promise in clinical trials recently. Simultaneously, significant pre-clinical progress has been made in several approaches to non-hormonal male contraceptives, including compounds that inhibit sperm motility such as EPPIN, compounds which inhibit retinoic acid binding or biosynthesis, and reversible approaches to obstruction of the vas deferens. It is imperative for both these areas of research to continue making strides so that there is a gamut of contraceptive options for couples to choose from. Some of these approaches will hopefully reach clinical utility soon, greatly improving contraceptive choice for couples. Recently, there have been several promising advances in male contraceptive research. Some of these approaches will hopefully reach clinical utility soon, greatly improving contraceptive choice for couples.
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影响因子：
6.7
作者：
Amory, John K.
通讯作者：
Amory, John K.
影响因子：
4.8
作者：
Chung, Sanny S. W.;Wang, Xiangyuan;Wolgemuth, Debra J.
通讯作者：
Wolgemuth, Debra J.
影响因子：
4.8
作者：
Attardi, Barbara J.;Hild, Sheri A.;Reel, Jerry R.
通讯作者：
Reel, Jerry R.
影响因子：
--
作者：
Attardi, Barbara J.;Marck, Brett T.;Hild, Sheri A.
通讯作者：
Hild, Sheri A.
影响因子：
4.8
作者：
Chung, Sanny S. W.;Wang, Xiangyuan;Wolgemuth, Debra J.
通讯作者：
Wolgemuth, Debra J.