Nutritional Supplementation of Naturally Occurring Vitamin D to Improve Hemorrhagic Stroke Outcomes.
Nutritional Supplementation of Naturally Occurring Vitamin D to Improve Hemorrhagic Stroke Outcomes.
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DOI：
10.3389/fneur.2021.670245
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发表时间：
2021
影响因子：
3.4
通讯作者：
Doré S
中科院分区：
文献类型：
--
作者：
Ashouri R;Fangman M;Brielmaier J;Fields ZA;Campo N;Doré S
维生素D缺乏，如果不及时治疗，与骨骼疾病，心血管损伤和缺血性中风的风险增加有关。虽然维生素D的自然摄入有多种营养选择，但我们希望阐明膳食维生素D在出血性卒中病理学中可能发挥的潜在机制。本范围审查概述了与维生素D的生化活性、维生素D缺乏对出血性卒中结局的影响以及营养性维生素D对出血性卒中结局的潜在益处相关的研究结果。在这里，我们分析了可能导致维生素D缺乏的相关因素，以及随后出血性卒中发生率较高且随后结局恶化的风险。维生素D用于减轻出血性卒中发作和卒中后结局的神经保护机制尚未得到彻底研究。然而，研究人员已经提出了几种潜在的保护机制，包括通过抑制活性氧的产生来减少血脑屏障障碍，通过降低促炎细胞因子的水平来减轻炎症，以及预防蛛网膜下腔出血和脑出血后的脑血管痉挛和迟发性脑缺血。虽然需要更多的研究，维生素D补充剂也有局限性，但维生素D作为一个整体可能在出血性中风的动力学中发挥重要作用。进一步的研究应该集中在扩大我们对维生素D的神经保护能力和机制的理解，以及维生素D补充剂如何作为出血性中风的有效治疗过程。
Vitamin D deficiency, if left untreated, is associated with bone disorders, cardiovascular damage, and an increased risk of ischemic stroke. While there are various nutritional options for the natural intake of vitamin D, we hope to elucidate the potential mechanisms dietary vitamin D may play in hemorrhagic stroke pathology. This scoping review outlines findings from studies relevant to the biochemical activity of vitamin D, the impact of vitamin D deficiency on hemorrhagic stroke outcomes, and the potential benefit of nutritional vitamin D on hemorrhagic stroke outcomes. Here, we analyze the relevant factors that can lead to vitamin D deficiency, and subsequently, a higher risk of hemorrhagic stroke incidence with worsened subsequent outcomes. The neuroprotective mechanisms through which vitamin D works to attenuate hemorrhagic stroke onset and post-stroke outcomes have not yet been thoroughly examined. However, researchers have proposed several potential protective mechanisms, including reduction of blood brain barrier disturbance by inhibiting the production of reactive oxygen species, mitigation of inflammation through a reduction of levels of proinflammatory cytokines, and prevention of cerebral vasospasm and delayed cerebral ischemia following subarachnoid hemorrhage and intracerebral hemorrhage. While more research is needed and there are limitations to vitamin D supplementation, vitamin D as a whole may play a significant role in the dynamics of hemorrhagic stroke. Further research should focus on expanding our understanding of the neuroprotective capacity and mechanisms of vitamin D, as well as how vitamin D supplementation could serve as an effective course of treatment of hemorrhagic strokes.
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影响因子：
2.4
作者：
Iqbal, Anoop Mohamed;Dahl, Amanda R.;Kumar, Seema
通讯作者：
Kumar, Seema
脑出血后，骨桥蛋白通过JAK2/STAT1途径通过JAK2/STAT1途径减轻炎症。
影响因子：
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通讯作者：
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影响因子：
4.8
作者：
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通讯作者：
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影响因子：
6.3
作者：
Enkhjargal, Budbazar;Malaguit, Jay;Zhang, John H.
通讯作者：
Zhang, John H.
影响因子：
4.8
作者：
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通讯作者：
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