Decreased survival in glioblastomas is specific to contact with the ventricular-subventricular zone, not subgranular zone or corpus callosum.
Decreased survival in glioblastomas is specific to contact with the ventricular-subventricular zone, not subgranular zone or corpus callosum.
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胶质母细胞瘤的存活率降低是与心室-心室下区接触所特有的，而不是颗粒下区或胼胝体。
DOI：
10.1007/s11060-017-2374-3
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发表时间：
2017-04
影响因子：
3.9
通讯作者：
Chambless LB
中科院分区：
文献类型：
--
作者：
Mistry AM;Dewan MC;White-Dzuro GA;Brinson PR;Weaver KD;Thompson RC;Ihrie RA;Chambless LB
胶质母细胞瘤（GBM）与神经源性区(NZ) -脑室-室下区（VSVZ）和亚颗粒区(SGZ) -以及胼胝体（CC）的x线接触的临床效果尚不清楚，在SGZ的情况下，尚未探索。我们研究了1)GBM与NZ接触是否与生存率降低相关；2)如果有，这种效应是否与特定的新西兰有关；3)如果放射学接触或GBM侵犯CC（可识别的最大白质束），则与生存率降低有关。我们回顾性地确定了207名接受细胞减少手术治疗GBM的成年患者，随后接受化疗和/或放疗。记录年龄、术前Karnofsky功能状态评分（KPS）和切除程度。术前盲目分析mri，计算肿瘤体积及与VSVZ、SGZ、CC、皮质的接触情况。计算总生存率（OS）和无进展生存率（PFS），并采用多变量Cox分析进行分析。207例患者中，111例GBM接触VSVZ (VSVZ+GBMs)， 23例SGZ+GBMs， 52例CC+GBMs， 164例皮质+GBMs。VSVZ+、SGZ+和CC+ GBMs的体积明显大于非接触对照。除了年龄、KPS、总切除、化疗和放疗外，多变量Cox生存分析显示，接触VSVZ是较低OS的独立预测因子，也是较低PFS和早期复发的唯一预测因子。GBM与VSVZ接触，但与SGZ、CC或皮质无关，与早期复发和生存率降低有关。我们假设VSVZ生态位具有独特的特性，有助于成人GBM的病理生物学。
The clinical effect of radiographic contact of glioblastoma (GBM) with neurogenic zones (NZ)—the ventricular-subventricular (VSVZ) and subgranular (SGZ) zones—and the corpus callosum (CC) remains unclear and, in the case of the SGZ, unexplored. We investigated 1) if GBM contact with a NZ correlates with decreased survival; 2) if so, whether this effect is associated with a specific NZ; and 3) if radiographic contact or invasion by GBM of the CC, the largest identifiable white matter tract, is associated with decreased survival. We retrospectively identified 207 adult patients who underwent cytoreductive surgery for GBM followed by chemotherapy and/or radiation. Age, preoperative Karnofsky performance status score (KPS), and extent of resection were recorded. Preoperative MRIs were blindly analyzed to calculate tumor volume and contact with VSVZ, SGZ, CC, and cortex. Overall (OS) and progression free (PFS) survivals were calculated and analyzed with multivariate Cox analyses. Among 207 patients, 111 had GBM contacting VSVZ (VSVZ+GBMs), 23 SGZ+GBMs, 52 CC+GBMs, and 164 cortex+GBMs. VSVZ+, SGZ+, and CC+ GBMs had significantly larger volume relative to non-contacting controls. In addition to age, KPS, gross total resection, chemotherapy, and radiation, multivariate Cox survival analyses revealed contact with VSVZ as an independent predictor of lower OS and the only predictor of lower PFS and early recurrence. GBM contact with the VSVZ, but not SGZ, CC, or cortex, is associated with early recurrence and decreased survival. We hypothesize that the VSVZ niche has unique properties that contribute to GBM pathobiology in adults.
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影响因子：
82.9
作者：
Eriksson, PS;Perfilieva, E;Gage, FH
通讯作者：
Gage, FH
影响因子：
3.9
作者：
Chaichana, Kaisorn L.;Jusue-Torres, Ignacio;Lemos, Ana Maria;Gokaslan, Aaron;Cabrera-Aldana, Eibar Ernesto;Ashary, Ahmed;Olivi, Alessandro;Quinones-Hinojosa, Alfredo
通讯作者：
Quinones-Hinojosa, Alfredo
DOI：
10.1016/j.radonc.2015.07.032
发表时间：
2015-08
期刊：
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
影响因子：
--
作者：
Chen L;Chaichana KL;Kleinberg L;Ye X;Quinones-Hinojosa A;Redmond K
通讯作者：
Redmond K
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
15.9
作者：
Jafri, Nazia F.;Clarke, Jennifer L.;Cha, Soonmee
通讯作者：
Cha, Soonmee