Brain Activity Unique to Orgasm in Women: An fMRI Analysis.
Brain Activity Unique to Orgasm in Women: An fMRI Analysis.
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DOI：
10.1016/j.jsxm.2017.08.014
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Komisaruk BR
中科院分区：
文献类型：
--
作者：
Wise NJ;Frangos E;Komisaruk BR
尽管有关女性和男性性唤起期间区域大脑活动成像的文献非常广泛且基本一致，但有关性高潮的文献相对有限且可变，部分原因是参与者的性高潮潜伏期和头部运动的可变性所带来的方法学挑战。比较高潮时（自我和伴侣诱发的）与生殖器刺激开始时、高潮开始前和高潮停止后的大脑活动，并升级获取和分析功能磁共振成像（fMRI）结果的方法。使用功能磁共振成像，我们对女性参与者响应自我和伴侣引起的阴蒂刺激的不同刺激和性高潮持续时间的等效时间点进行了采样。将第一个 20 秒的性高潮时期与刺激开始时以及性高潮前后的 20 秒时期进行对比。对感兴趣的全脑和脑干区域进行了单独的分析。为了对高潮前后阶段进行更细粒度的分析，我们对感兴趣的区域进行了时间过程分析。使用定制的热塑性整体头部和颈托稳定器，将头部运动最小化至平均小于 1.3 毫米。十名女性在西门子 3-T Trio fMRI 扫描仪中经历了由自我和伴侣诱导的生殖器刺激引发的性高潮。大脑活动在性高潮前逐渐增加，在性高潮时达到顶峰，然后下降。我们没有发现高潮前或高潮期间大脑区域失活的证据。激活的大脑区域包括感觉、运动、奖赏、额叶皮质和脑干区域（例如伏隔核、岛叶、前扣带皮层、眶额皮质、鳃盖、直角回、旁中央小叶、小脑、海马、杏仁核、下丘脑、腹侧被盖区和中缝背侧）。从目前的研究结果中获得的见解可以为治疗性高潮障碍（包括性快感缺失症）提供合理的基础指导。这显然是第一个针对女性自我和伴侣诱发的生殖器刺激引起性高潮的功能磁共振成像研究。本研究成功地应用了针对过度头部运动和性高潮可变延迟所带来的技术问题的方法学解决方案，从而能够识别涉及性高潮的大脑区域。局限性包括样本量小（N = 10），它结合了自我和伴侣诱导的刺激数据集进行分析，并验证了我们结论的概括。性高潮时，广泛的皮质、皮质下和脑干区域的活动达到峰值。
Although the literature on imaging of regional brain activity during sexual arousal in women and men is extensive and largely consistent, that on orgasm is relatively limited and variable, owing in part to the methodologic challenges posed by variability in latency to orgasm in participants and head movement. To compare brain activity at orgasm (self- and partner-induced) with that at the onset of genital stimulation, immediately before the onset of orgasm, and immediately after the cessation of orgasm and to upgrade the methodology for obtaining and analyzing functional magnetic resonance imaging (fMRI) findings. Using fMRI, we sampled equivalent time points across female participants’ variable durations of stimulation and orgasm in response to self- and partner-induced clitoral stimulation. The first 20-second epoch of orgasm was contrasted with the 20-second epochs at the beginning of stimulation and immediately before and after orgasm. Separate analyses were conducted for whole-brain and brainstem regions of interest. For a finer-grained analysis of the peri-orgasm phase, we conducted a time-course analysis on regions of interest. Head movement was minimized to a mean less than 1.3 mm using a custom-fitted thermoplastic whole-head and neck brace stabilizer. Ten women experienced orgasm elicited by self- and partner-induced genital stimulation in a Siemens 3-T Trio fMRI scanner. Brain activity gradually increased leading up to orgasm, peaked at orgasm, and then decreased. We found no evidence of deactivation of brain regions leading up to or during orgasm. The activated brain regions included sensory, motor, reward, frontal cortical, and brainstem regions (eg, nucleus accumbens, insula, anterior cingulate cortex, orbitofrontal cortex, operculum, right angular gyrus, paracentral lobule, cerebellum, hippocampus, amygdala, hypothalamus, ventral tegmental area, and dorsal raphe). Insight gained from the present findings could provide guidance toward a rational basis for treatment of orgasmic disorders, including anorgasmia. This is evidently the first fMRI study of orgasm elicited by self- and partner-induced genital stimulation in women. Methodologic solutions to the technical issues posed by excessive head movement and variable latencies to orgasm were successfully applied in the present study, enabling identification of brain regions involved in orgasm. Limitations include the small sample (N = 10), which combined self- and partner-induced stimulation datasets for analysis and which qualify the generalization of our conclusions. Extensive cortical, subcortical, and brainstem regions reach peak levels of activity at orgasm.
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影响因子：
5.7
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Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
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