Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.
Common variants on 8p12 and 1q24.2 confer risk of schizophrenia.
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8p12 和 1q24.2 的常见变异会带来精神分裂症的风险
作者：
精神分裂症是一种严重的精神障碍，影响世界人口的1%，遗传率高达80%。为了确定新的常见遗传危险因素，我们在中国汉族人群中进行了全基因组关联研究（GWAS）。发现样本集包括3，750名患者和6，468名健康对照（来自北方汉族的1，578例和1，592例对照;来自中原汉族的1，238例和2，856例对照;来自南方汉族的934例和2，020例对照）;我们在另外一个独立的队列中对4,383例病例和4,539例对照进行了随访。荟萃分析确定了染色体8 p12（rs 16887244，P=1.27×10−10）和1q24.2（rs 10489202，P=9.50×10−9）上常见SNP与精神分裂症的全基因组显著关联。我们的发现为精神分裂症的发病机制提供了新的见解。
Schizophrenia is a severe mental disorder affecting ~1% of the world population, with heritability of up to 80%. To identify new common genetic risk factors, we performed a genome-wide association study (GWAS) in the Han Chinese population. The discovery sample set consisted of 3,750 patients and 6,468 healthy controls (1,578 cases and 1,592 controls from the Northern Han; 1,238 cases and 2,856 controls from the Central Han; 934 cases and 2,020 controls from the Southern Han); and we followed up the top association signals in an additional independent cohort of 4,383 cases and 4,539 controls from the Han Chinese. Meta-analysis identified genome-wide significant association of common SNPs with schizophrenia on chromosome 8p12 (rs16887244, P=1.27×10−10) and 1q24.2 (rs10489202, P=9.50×10−9). Our findings provide new insights into the pathogenesis of schizophrenia.
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影响因子：
44.1
作者：
Shi, YY;He, L
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