Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study.
Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study.
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DOI：
10.1186/1471-2377-11-37
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发表时间：
2011-03-24
期刊：
影响因子：
2.6
通讯作者：
Patcai J
中科院分区：
文献类型：
--
作者：
Moldofsky H;Patcai J
严重急性呼吸系统综合症（SARS）是一种病毒性疾病，其长期不良影响尚不清楚。22名多伦多受试者的睡眠生理学、躯体和情绪症状，其中21名为医护人员，（19名女性，3名男性，平均年龄46.29岁+/- 11.02）仍然无法返回其原来的职业（平均19.8个月，范围：SARS后13至36个月）与7名健康女性受试者进行了比较。由于这些SARS后受试者与纤维肌痛综合征（FMS）患者的临床相似性，因此将其与21名无药物女性患者（平均年龄42.4 ± 11.8岁）进行了相似的比较。符合纤维肌痛的标准慢性SARS后的特征是持续疲劳、弥漫性肌痛、虚弱、抑郁和非恢复性睡眠，伴有REM相关的呼吸暂停/呼吸不足、睡眠EEG周期性交替模式升高和α EEG睡眠异常。SARS后患者的睡眠前后疲劳和睡眠后嗜睡症状与FMS患者相似，与慢性疲劳综合征患者相似。SARS后和FMS组均存在睡眠不稳定，表现为睡眠EEG周期性交替模式率较高。与FMS患者相比，SARS后组的α EEG睡眠异常评分较低。SARS后的一组也报告了较少的睡眠前和睡眠后肌肉骨骼疼痛症状。慢性SARS后的临床和睡眠特征形成了慢性疲劳、疼痛、虚弱、抑郁和睡眠障碍的综合征，与FMS和慢性疲劳综合征的临床和睡眠特征重叠。
The long term adverse effects of Severe Acute Respiratory Syndrome (SARS), a viral disease, are poorly understood. Sleep physiology, somatic and mood symptoms of 22 Toronto subjects, 21 of whom were healthcare workers, (19 females, 3 males, mean age 46.29 yrs.+/- 11.02) who remained unable to return to their former occupation (mean 19.8 months, range: 13 to 36 months following SARS) were compared to 7 healthy female subjects. Because of their clinical similarities to patients with fibromyalgia syndrome (FMS) these post-SARS subjects were similarly compared to 21 drug free female patients, (mean age 42.4 +/- 11.8 yrs.) who fulfilled criteria for fibromyalgia. Chronic post-SARS is characterized by persistent fatigue, diffuse myalgia, weakness, depression, and nonrestorative sleep with associated REM-related apneas/hypopneas, an elevated sleep EEG cyclical alternating pattern, and alpha EEG sleep anomaly. Post- SARS patients had symptoms of pre and post-sleep fatigue and post sleep sleepiness that were similar to the symptoms of patients with FMS, and similar to symptoms of patients with chronic fatigue syndrome. Both post-SARS and FMS groups had sleep instability as indicated by the high sleep EEG cyclical alternating pattern rate. The post-SARS group had a lower rating of the alpha EEG sleep anomaly as compared to the FMS patients. The post-SARS group also reported less pre-sleep and post-sleep musculoskeletal pain symptoms. The clinical and sleep features of chronic post-SARS form a syndrome of chronic fatigue, pain, weakness, depression and sleep disturbance, which overlaps with the clinical and sleep features of FMS and chronic fatigue syndrome.
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影响因子：
10
作者：
Hui, DS;Joynt, GM;Sung, JJY
通讯作者：
Sung, JJY
影响因子：
168.9
作者：
COPE, H;DAVID, A;MANN, A
通讯作者：
MANN, A
影响因子：
56.9
作者：
Lombardi, Vincent C.;Ruscetti, Francis W.;Mikovits, Judy A.
通讯作者：
Mikovits, Judy A.
DOI：
10.1164/ajrccm.160.6.9811054
发表时间：
1999-12-01
影响因子：
24.7
作者：
Grote, L;Ploch, T;Peter, JH
通讯作者：
Peter, JH
严重的急性呼吸综合症对身体状况和生活质量的影响。
影响因子：
4.3
作者：
Lau HM;Lee EW;Wong CN;Ng GY;Jones AY;Hui DS
通讯作者：
Hui DS