Increased Prevalence of Severe Fever with Thrombocytopenia Syndrome in Eastern China Clustered with Multiple Genotypes and Reasserted Virus during 2010-2015.
Increased Prevalence of Severe Fever with Thrombocytopenia Syndrome in Eastern China Clustered with Multiple Genotypes and Reasserted Virus during 2010-2015.
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2010-2015年华东地区多基因型和病毒复发的发热伴血小板减少综合征患病率上升
DOI：
10.1038/s41598-017-06853-1
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发表时间：
2017-07-26
影响因子：
4.6
通讯作者：
Bao C
中科院分区：
文献类型：
--
作者：
Li Z;Hu J;Cui L;Hong Y;Liu J;Li P;Guo X;Liu W;Wang X;Qi X;Wu B;Feng Z;Shen A;Liu X;Zhao H;Tan W;Zhou J;Xing Z;Bao C
严重发热伴血小板减少综合征(SFTS)是一种新型的、病死率较高的硬虱传播的病毒性疾病。自2010年1月以来，我们在江苏和安徽两省开展了流行性感冒的流行病学监测和病原学研究。2010年1月至2015年12月，江苏、安徽两省共确诊流行性出血热病例286例，病死率16.1%。大多数确诊的流行性感冒病例分布在江苏和安徽两省交界地区。我们的发现表明，SFTS的患病率自2010年以来一直在上升，并在2015年达到最高水平。系统进化分析表明，江苏省和安徽省分离的病毒株大部分(83.6%)属于A型和D型。值得注意的是，有3株毒株聚为E型。这是国内首次报道E型毒株。在疫区中部地区，A、C、D三种基因型共存，出现A、D两型间的重排。
Severe fever with thrombocytopenia syndrome (SFTS) is a novel tick-borne viral disease with high mortality. Since January 2010, we have conducted an epidemiological surveillance and etiological study of SFTS in Jiangsu and Anhui provinces. From January 2010 through December 2015, a total of 286 SFTS cases were confirmed in Jiangsu and Anhui provinces with a case fatality rate of 16.1%. The majority of confirmed SFTS cases were distributed in the border area of Jiangsu and Anhui provinces. Our findings suggest that the SFTS prevalence rate rose since 2010 and reached its highest in 2015. Phylogenetic analysis demonstrated that the majority of the SFTSV strains (83.6%) from Jiangsu and Anhui provinces belonged to genotypes A and D. Notably, we identified three strains of SFTSV clustered into the genotype E. This is the first report of the genotype E SFTSV strains in mainland of China. A reassortment between genotype A and D was found in the central region of the endemic areas, where three SFTSV genotypes (A, C and D) were co-circulating.
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影响因子：
3.7
作者：
Padidam, M;Sawyer, S;Fauquet, CM
通讯作者：
Fauquet, CM
影响因子：
3.7
作者：
Ding S;Niu G;Xu X;Li J;Zhang X;Yin H;Zhang N;Jiang X;Wang S;Liang M;Wang X;Yu XJ
通讯作者：
Yu XJ
影响因子：
3.7
作者：
Deng B;Zhou B;Zhang S;Zhu Y;Han L;Geng Y;Jin Z;Liu H;Wang D;Zhao Y;Wen Y;Cui W;Zhou Y;Gu Q;Sun C;Lu X;Wang W;Wang Y;Li C;Wang Y;Yao W;Liu P
通讯作者：
Liu P
中国一种新型布尼亚病毒引起的发热伴血小板减少症。
DOI：
10.1056/nejmoa1010095
发表时间：
2011-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Yu XJ;Liang MF;Zhang SY;Liu Y;Li JD;Sun YL;Zhang L;Zhang QF;Popov VL;Li C;Qu J;Li Q;Zhang YP;Hai R;Wu W;Wang Q;Zhan FX;Wang XJ;Kan B;Wang SW;Wan KL;Jing HQ;Lu JX;Yin WW;Zhou H;Guan XH;Liu JF;Bi ZQ;Liu GH;Ren J;Wang H;Zhao Z;Song JD;He JR;Wan T;Zhang JS;Fu XP;Sun LN;Dong XP;Feng ZJ;Yang WZ;Hong T;Zhang Y;Walker DH;Wang Y;Li DX
通讯作者：
Li DX
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影响因子：
3.8
作者：
Li Z;Bao C;Hu J;Liu W;Wang X;Zhang L;Ji Z;Feng Z;Li L;Shen A;Liu X;Zhao H;Tan W;Zhou J;Qi X;Zhu Y;Tang F;Cardona CJ;Xing Z
通讯作者：
Xing Z