A Normalized Shear Deformation Indicator for Ultrasound Strain Elastography in Breast Tissues: An In Vivo Feasibility Study.
A Normalized Shear Deformation Indicator for Ultrasound Strain Elastography in Breast Tissues: An In Vivo Feasibility Study.
复制标题
DOI：
10.1155/2018/2053612
复制
发表时间：
2018
影响因子：
--
通讯作者：
Peng B
中科院分区：
文献类型：
--
作者：
Jiang J;Peng B
载荷下的剪切变形包含区分乳腺良性病变和恶性病变的有用信息。在本研究中，我们提出了一种源自主应变概念的归一化剪切变形指标（NSDI）。由于 NSDI 需要高质量的轴向和横向（分别平行和垂直于光束）位移估计，因此采用了将高质量散斑跟踪与信号“去噪”相结合的策略。这两种技术之前均由我们小组发表。使用有限元 (FE) 模型来确定乳腺病灶内和周围 NSDI 值升高的可能原因，然后对从 26 个活检证实的体内乳腺病灶获取的超声数据进行分析。我们发现，理论上，NSDI 值升高可归因于两个因素：组织硬度显着硬化和异质性增加。体内数据分析表明，与良性癌症相比，恶性癌症中拟议的 NSDI 值更高（p < 0.05）。总之，我们的初步结果表明，NSDI值的计算是可行的，并且NSDI可以利用现有的临床设备作为后处理工具为乳腺病变鉴别增加价值。
The shear deformation under loads contains useful information for distinguishing benign breast lesions from malignant ones. In this study, we proposed a normalized shear deformation indicator (NSDI) that was derived from the concept of principal strains. Since the NSDI requires both high-quality axial and lateral (parallel and perpendicular to the beam, resp.) displacement estimates, a strategy combining high-quality speckle tracking with signal “denoising” was employed. Both techniques were previously published by our group. Finite element (FE) models were used to identify possible causes for elevated NSDI values in and around breast lesions, followed by an analysis of ultrasound data acquired from 26 biopsy-confirmed in vivo breast lesions. We found that, theoretically, the elevated NSDI values could be attributed to two factors: significantly hardened tissue stiffness and increasing heterogeneity. The analysis of in vivo data showed that the proposed NSDI values were higher (p < 0.05) among malignant cancers as compared to those measured from benign ones. In conclusion, our preliminary results demonstrated that the calculation of NSDI value is feasible and NSDI could add value to breast lesion differentiation with current clinical equipment as a postprocessing tool.
登录
查看更多内容
影响因子：
3.4
作者：
Hille, H.;Vetter, M.;Hackeloeer, B. J.
通讯作者：
Hackeloeer, B. J.
DOI：
10.1109/58.677757
发表时间：
1998-05-01
影响因子：
3.6
作者：
Anderson, ME
通讯作者：
Anderson, ME
影响因子：
10.6
作者：
Goenezen S;Dord JF;Sink Z;Barbone PE;Jiang J;Hall TJ;Oberai AA
通讯作者：
Oberai AA
影响因子：
19.7
作者：
Burnside, Elizabeth S.;Hall, Timothy J.;Hangiandreou, Nicholas J.
通讯作者：
Hangiandreou, Nicholas J.
影响因子：
3.9
作者：
Golshan, M;Fung, BB;Morrow, M
通讯作者：
Morrow, M