Polyandry and the decrease of a selfish genetic element in a wild house mouse population.
Polyandry and the decrease of a selfish genetic element in a wild house mouse population.
复制标题
一妻多夫制和野生家鼠种群中自私遗传因素的减少。
DOI：
10.1111/j.1558-5646.2011.01336.x
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发表时间：
2011-09
期刊：
影响因子：
--
通讯作者：
Bagheri HC
中科院分区：
文献类型：
--
作者：
Manser A;Lindholm AK;König B;Bagheri HC
尽管t单倍型对个体有害，但它是一种自私的遗传元素，存在于许多家鼠种群中。通过扭曲传递比，+/t雄性将t单倍型传递给高达90%的后代。然而，t/t个体在子宫中死亡。基于这些性质的理论模型预测的t频率比观测到的要高得多，导致了t悖论。在这里，我们使用经验领域的数据和理论方法来调查一夫多妻制是否是女性对抗这种扭曲的负面适应后果的一种策略。我们发现，在5.5年的时间里，t频率显著下降，这不能用传输率扭曲和隐性致死的影响来解释，尽管+/t女性的预期寿命明显高于+/+女性。我们量化了生活史数据以及纯合子和杂合子健康效应。种群细分和近亲交配被排除为影响t系统的进化力量。然后应用随机模型研究了一夫多妻制对t系统的可能影响。模拟表明，一夫多妻制可以解释观察到的t动态，这使它成为一种生物学上看似合理的解释，可以解释自然种群中普遍存在的低t频率。
Despite deleterious effects on individuals, the t haplotype is a selfish genetic element present in many house mouse populations. By distorting the transmission ratio, +/t males transmit the t haplotype to up to 90% of their offspring. However, t/t individuals perish in utero. Theoretical models based on these properties predict a much higher t frequency than observed, leading to the t paradox. Here, we use empirical field data and theoretical approaches to investigate whether polyandry is a female counterstrategy against the negative fitness consequences of such distorters. We found a significant decrease of the t frequency over a period of 5.5 years that cannot be explained by the effect of transmission ratio distortion and recessive lethals, despite significantly higher life expectancy of +/t females compared to +/+ females. We quantified life-history data and homozygous and heterozygous fitness effects. Population subdivision and inbreeding were excluded as evolutionary forces influencing the t system. The possible influence of polyandry on the t system was then investigated by applying a stochastic model to this situation. Simulations show that polyandry can explain the observed t dynamics, making it a biologically plausible explanation for low t frequencies in natural populations in general.
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