Oscillatory Dynamics and In Vivo Photoacoustic Imaging Performance of Plasmonic Nanoparticle-Coated Microbubbles.
Oscillatory Dynamics and In Vivo Photoacoustic Imaging Performance of Plasmonic Nanoparticle-Coated Microbubbles.
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DOI：
10.1002/smll.201403398
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发表时间：
2015-07-01
期刊：
影响因子：
13.3
通讯作者：
Hossack, John A.
中科院分区：
文献类型：
--
作者：
Dixon, Adam J.;Hu, Song;Klibanov, Alexander L.;Hossack, John A.
在其表面上带有浆膜纳米颗粒的微泡为光声和超声成像提供了对比度，在这项工作中，使用高速脉冲激发的微泡与表面结合的金纳米棒的响应（称为AUMBS）和数值模型。但是，微泡壁运动可忽略不计对低激光器的AUMB光声反应是由从表面结合的纳米棒到微泡气芯的导电热传递而产生的，尽管在较高的燃料中，爆炸性沸腾可能会在纳米棒表面发生，从而产生蒸汽纳米泡，这有助于快速的AUMB膨胀。对比。现有的非侵入性光声和超声成像应用的对比剂。
在其表面上具有金纳米棒的微泡会暴露于低脉冲激光和高能量兴奋时，微泡会经历纳米辐射射击，而对较高的激光能量响应较高的激光能量快速微观的扩展。
Microbubbles bearing plasmonic nanoparticles on their surface provide contrast enhancement for both photoacoustic and ultrasound imaging. In this work, the responses of microbubbles with surface-bound gold nanorods – termed AuMBs – to nanosecond pulsed laser excitation were studied using high-speed microscopy, photoacoustic imaging, and numerical modeling. In response to laser fluences below 5 mJ cm−2, AuMBs produce weak photoacoustic emissions and exhibit negligible microbubble wall motion. However, in reponse to fluences above 5 mJ cm−2, AuMBs undergo dramatically increased thermal expansion and emit nonlinear photoacoustic waves of over 10-fold greater amplitude than would be expected from freely dispersed gold nanorods. Numerical modeling suggests that AuMB photoacoustic responses to low laser fluences result from conductive heat transfer from the surface-bound nanorods to the microbubble gas core, whereas at higher fluences, explosive boiling may occur at the nanorod surface, producing vapor nanobubbles that contribute to rapid AuMB expansion. The results of this study indicate that AuMBs are capable of producing acoustic emissions of significantly higher amplitude than those produced by conventional sources of photoacoustic contrast. In vivo imaging performance of AuMBs in a murine kidney model suggests that AuMBs may be an effective alternative to existing contrast agents for non-invasive photoacoustic and ultrasound imaging applications. Microbubbles with gold nanorods on their surface exhibit different behaviors when exposed to low and high pulsed laser energy. In response to low energy excitation, the microbubble undergoes nanometer radial oscillations, while in response to higher laser energies, vapor nanobubble formation on the microbubble surface drives rapid microscale expansion. We demonstrate that these agents provide contrast enhancement for both ultrasound and photoacoustic imaging in vivo.
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影响因子：
3.5
作者：
Chomas, JE;Dayton, P;Ferrara, K
通讯作者：
Ferrara, K
影响因子：
2.9
作者：
Dou, YS;Zhigilei, LV;Garrison, BJ
通讯作者：
Garrison, BJ
影响因子：
6.7
作者：
Gorce, JM;Arditi, M;Schneider, M
通讯作者：
Schneider, M
来自等离子体纳米颗粒的光声波的环境依赖性产生。
影响因子：
13.3
作者：
Chen, Yun-Sheng;Frey, Wolfgang;Aglyamov, Salavat;Emelianov, Stanislav
通讯作者：
Emelianov, Stanislav
影响因子：
17.1
作者：
Hannah A;Luke G;Wilson K;Homan K;Emelianov S
通讯作者：
Emelianov S