Intra-Organ Delivery of Nanotherapeutics for Organ Transplantation.
Intra-Organ Delivery of Nanotherapeutics for Organ Transplantation.
复制标题
器官移植中纳米疗法的器官内给药。
DOI：
10.1021/acsnano.1c04707
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发表时间：
2021-11-23
期刊：
影响因子：
17.1
通讯作者：
Abdi, Reza
中科院分区：
文献类型：
--
作者：
Hussain, Bilal;Kasinath, Vivek;Madsen, Joren C.;Bromberg, Jonathan;Tullius, Stefan G.;Abdi, Reza
关键词：
通过使用纳米颗粒（NPs）靶向递送治疗药物已经成为一种有前途的方法，可以提高其疗效并减少其副作用。NPs可以通过结合细胞特异性受体的配体来定位于选择性组织。尽管绝大多数纳米递送平台都集中在癌症治疗上，但人们已经开始努力将纳米疗法引入免疫学和移植领域。在这篇文章中，我们从临床医生的角度概述了目前的纳米治疗策略，在从供体器官采集到植入受体之间的时间间隔内使用NPs治疗实体器官移植，这是一项创新技术，可以为移植患者提供重大益处。体外恒温机器灌注（NMP）的使用与移植后器官功能的保存有关，也为在这一关键时期将纳米治疗药物局部、持续和受控地输送到器官提供了理想的机会。在这里，我们总结了以前通过在受体体内放置NPs治疗器官来改善移植结果的努力。在这一新兴研究领域的研究是有希望的，但需要更广泛的研究来克服生理上的挑战，以实现有效的纳米治疗递送到移植器官。
Targeted delivery of therapeutics through the use of nanoparticles (NPs) has emerged as a promising method that increases their efficacy and reduces their side effects. NPs can be tailored to localize to selective tissues through conjugation to ligands that bind cell-specific receptors. Although the vast majority of nanodelivery platforms have focused on cancer therapy, efforts have begun to introduce nanotherapeutics to the fields of immunology as well as transplantation. In this article, we provide an overview from a clinician’s perspective of current nanotherapeutic strategies to treat solid organ transplants with NPs during the time interval between organ harvest from the donor and placement into the recipient, an innovative technology that can provide major benefits to transplant patients. The use of ex vivo normothermic machine perfusion (NMP), which is associated with preserving the function of the organ following transplantation, also provides an ideal opportunity for a localized, sustained, and controlled delivery of nanotherapeutics to the organ during this critical time period. Here, we summarize previous endeavors to improve transplantation outcomes by treating the organ with NPs prior to placement in the recipient. Investigations in this burgeoning field of research are promising, but more extensive studies are needed to overcome the physiological challenges to achieving effective nanotherapeutic delivery to transplanted organs discussed in this review.
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影响因子：
4.6
作者：
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通讯作者：
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影响因子：
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影响因子：
64.5
作者：
Cocucci E;Aguet F;Boulant S;Kirchhausen T
通讯作者：
Kirchhausen T
金纳米颗粒的几何形状和表面特征会影响其生物分布和巨噬细胞的吸收。
DOI：
10.1016/j.ejpb.2010.11.010
发表时间：
2011-04
期刊：
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
影响因子：
--
作者：
Arnida;Janát-Amsbury MM;Ray A;Peterson CM;Ghandehari H
通讯作者：
Ghandehari H