Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages.
Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages.
复制标题
金纳米颗粒的几何形状和表面特征会影响其生物分布和巨噬细胞的吸收。
DOI：
10.1016/j.ejpb.2010.11.010
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Ghandehari H
中科院分区：
文献类型：
--
作者：
Arnida;Janát-Amsbury MM;Ray A;Peterson CM;Ghandehari H
对表面聚乙二醇链（PEG）的球形和棒状金纳米颗粒进行了尺寸、形状、电荷、聚分散性和表面等离子体共振表征。将纳米颗粒静脉注射至6-8周龄雌性原位卵巢肿瘤nu/nu小鼠，比较其在重要器官中的生物分布。与球形金纳米棒相比，金纳米棒被肝脏吸收的程度更小，在血液中的循环时间更长，在肿瘤中的积累也更高。小鼠巨噬细胞样细胞系对聚乙二醇化金纳米颗粒的细胞摄取作为几何函数进行了研究。与纳米球相比，聚乙二醇化金纳米棒被巨噬细胞吸收的程度较小。这些研究指出了金纳米粒子的几何形状和表面性质对跨越生物屏障的运输的重要性。
Spherical and rod-shaped gold nanoparticles with surface poly (ethylene glycol) (PEG) chains were characterized for size, shape, charge, poly dispersity and surface plasmon resonance. The nanoparticles were injected intravenously to 6–8 weeks old female nu/nu mice bearing orthotopic ovarian tumors and their biodistribution in vital organs was compared. Gold nanorods were taken up to a lesser extent by the liver, had longer circulation time in the blood, and higher accumulation in the tumors, compared with their spherical counterparts. The cellular uptake of PEGylated gold nanoparticles by a murine macrophage-like cell line as a function of geometry was examined. Compared to nanospheres, PEGylated gold nanorods were taken up to a lesser extent by macrophages. These studies point to the importance of gold nanoparticle geometry and surface properties on transport across biological barriers.
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DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
4
作者：
GORDON, S
通讯作者：
GORDON, S
影响因子：
5.8
作者：
Levchenko, TS;Rammohan, R;Torchilin, VP
通讯作者：
Torchilin, VP
影响因子：
3.3
作者：
Arnida;Malugin, Alexander;Ghandehari, Hamidreza
通讯作者：
Ghandehari, Hamidreza
影响因子：
10.8
作者：
Maeda, H;Wu, J;Hori, K
通讯作者：
Hori, K