Relationship of gender and age on thyroid hormone parameters in a large Chinese population.
Relationship of gender and age on thyroid hormone parameters in a large Chinese population.
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中国大量人群中性别和年龄对甲状腺激素参数的关系
DOI：
10.20945/2359-3997000000179
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发表时间：
2020-02
影响因子：
1.7
通讯作者：
Xie, Zhen
中科院分区：
文献类型：
--
作者：
Chen, Xinxin;Zheng, Xulei;Ding, Zhaojun;Su, Yang;Wang, Shu;Cui, Bin;Xie, Zhen
摘要目的本研究旨在探讨中国碘摄入量充足人群中年龄和性别对甲状腺激素水平的影响。研究对象和方法共纳入83643人，并按年龄和性别进行分层。计算18~80岁每10年男女促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)和FT3/FT4比值的中位数、2.5和97.5。用广义加性模型(GAM)中的光滑样条法估计TSH、FT3、FT4、FT3/FT4在男女各年龄组中的分布。比较不同年龄组间TSH水平的性别差异。结果80岁以上年龄组TSH水平(中位数：2.57mIU/L，2.5~97.5：0.86~7.56mIU/L)显著高于其他年龄组(P<；0.001)。各年龄段女性TSH值均高于男性(P<；0.001)。平滑曲线结果表明，TSH随年龄增长而升高，FT3浓度男性高于女性，FT3/FT4比值的变化趋势与FT3基本一致。50岁组TSH浓度(女性中位数2.48mIU/L，男性2.00mIU/L)显著高于30岁组(女性中位数2.18mIU/L，男性中位数1.85mIU/L)。结论女性和老年人的FT3值和FT3/FT4比值较低，而FT4值保持不变，与TSH值随年龄增长相一致。
ABSTRACT Objective This study aimed to present the impact of age and gender on thyroid hormone levels in a large Chinese population with sufficient iodine intake. Subjects and methods A total of 83643 individuals were included and were stratified by age and gender. The median, 2.5th and 97.5th of thyrotropin (TSH), free triiodothyronine (FT3), free thyroxine (FT4) and FT3/FT4 ratio were calculated for both genders for every decade from 18 to over 80 years. TSH, FT3, FT4, FT3/FT4 distribution in each age group was evaluated for females and males using smoothing splines in the generalized additive models (GAM). TSH concentrations were compared in the different age groups in gender. Results In the over 80s age group, the TSH level (median: 2.57 mIU/L, 2.5th-97.5th: 0.86-7.56 mIU/L) was significantly higher than other age groups, irrespective to gender (P<0.001). Females had a higher TSH value than males in all age groups (P<0.001). Results of the smoothing curves showed that TSH increased with age, FT3 concentration was higher in males than in females and the tendency of the FT3/FT4 ratio was basically similar to that of FT3. TSH concentration in the 50s age group (median 2.48 mIU/L for females versus 2.00 mIU/L for males) was significantly higher than that in the 30s age group (median 2.18 mIU/L for females versus median 1.85 mIU/L for males). Conclusions In accord with increasing TSH values during aging, females and older adults have lower FT3 values and lower FT3/FT4 ratios, while the FT4 values remain stable.
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影响因子：
2
作者：
Li, Chenyan;Guan, Haixia;Shan, Zhongyan
通讯作者：
Shan, Zhongyan
影响因子：
6.6
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影响因子：
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作者：
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通讯作者：
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影响因子：
6.6
作者：
Ehrenkranz, Joel;Bach, Phillip R.;Benvenga, Salvatore
通讯作者：
Benvenga, Salvatore