Early Initiation of Amphetamine-Type Stimulants (ATS) Use Associated with Lowered Cognitive Performance among Individuals with Co-Occurring Opioid and ATS Use Disorders in Malaysia.
Early Initiation of Amphetamine-Type Stimulants (ATS) Use Associated with Lowered Cognitive Performance among Individuals with Co-Occurring Opioid and ATS Use Disorders in Malaysia.
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苯丙胺型刺激剂（ATS）的早期开始使用与马来西亚同时发生的阿片类药物和ATS使用障碍相关的认知性能降低相关。
DOI：
10.1080/02791072.2017.1342152
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发表时间：
2017-09
影响因子：
2.8
通讯作者：
Chawarski MC
中科院分区：
文献类型：
--
作者：
Chooi WT;Mohd Zaharim N;Desrosiers A;Ahmad I;Yasin MAM;Syed Jaapar SZ;Schottenfeld RS;Vicknasingam BK;Chawarski MC
苯丙胺类兴奋剂的使用在马来西亚日益普遍，包括在同时使用类阿片的个人中。我们评估了同时存在阿片类药物和ATS依赖的个体的认知功能特征及其药物使用的终生模式。入组丁丙诺啡/纳洛酮治疗（伴或不伴托莫西汀）临床试验的受试者（N=50）完成了Raven标准进展矩阵、Rey-Osterrieth复杂图形测试、数字广度、连线和符号数字替换任务。进行多维尺度和K均值聚类分析，将参与者分为较低和较高的认知表现组。随后，进行方差分析程序，以评估药物使用史和人口统计学的组间差异。确定了两组具有不同认知表现的个人。在控制药物使用的总体持续时间的情况下，较低认知能力组的开始使用ATS的年龄显著早于较高认知能力组：20.9（95% CI：18.0 - 23.8）vs 25.2（95% CI：22.4 - 28.0，p = 0.038）。虽然安非他明类兴奋剂的使用对认知功能的不利影响在年龄较小时可能特别明显，可能与发育中的大脑更容易受到这些药物的刺激和/或神经毒性作用的影响有关，但目前的研究结果不能排除安非他明类兴奋剂使用前认知能力的降低。
Amphetamine-type stimulants (ATS) use is increasingly prevalent in Malaysia, including among individuals who also use opioids. We evaluated cognitive functioning profiles among individuals with co-occurring opioid and ATS dependence and their lifetime patterns of drug use. Participants (N=50) enrolling in a clinical trial of buprenorphine/naloxone treatment with or without atomoxetine completed the Raven’s Standard Progressive Matrices, Rey-Osterrieth Complex Figure test, Digit Span, Trail Making and Symbol Digit Substitution tasks. Multidimensional scaling and a K-means cluster analyses were conducted to classify participants into lower versus higher cognitive performance groups. Subsequently, analyses of variance procedures were conducted to evaluate between group differences on drug use history and demographics. Two clusters of individuals with distinct profiles of cognitive performance were identified. The age of ATS use initiation, controlling for the overall duration of drug use, was significantly earlier in the lower than in the higher cognitive performance cluster: 20.9 (95% CI: 18.0 – 23.8) versus 25.2 (95% CI: 22.4 – 28.0, p = 0.038). While adverse effects of ATS use on cognitive functioning can be particularly pronounced with younger age, potentially related to greater vulnerability of the developing brain to stimulant and/or neurotoxic effects of these drugs, the current study findings cannot preclude lowered cognitive performance before initiation of ATS use.
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影响因子：
14.8
作者：
Bowie, Christopher R.;Harvey, Philip D.
通讯作者：
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