Antimicrobial Efficacy and Cell Adhesion Inhibition of In Situ Synthesized ZnO Nanoparticles/Polyvinyl Alcohol Nanofibrous Membranes
Antimicrobial Efficacy and Cell Adhesion Inhibition of In Situ Synthesized ZnO Nanoparticles/Polyvinyl Alcohol Nanofibrous Membranes
复制标题
原位合成ZnO纳米颗粒/聚乙烯醇纳米纤维膜的抗菌功效和细胞粘附抑制
DOI：
10.1155/2016/6394124
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Li Ping
中科院分区：
文献类型：
--
作者：
Li Jian;Zhang Qun;Xu Minjing;Wu Changzhu;Li Ping
Nanoparticle metal oxides are emerging as a new class of important materials in medical, agricultural, and industrial applications. In this context, free zinc oxide (ZnO) nanoparticles (NPs) have been increasingly shown with broad antimicrobial activities. However, biological properties of immobilized ZnO NPs on matrixes like nanofibrous membranes are still limited. In this study, in situ synthesized ZnO NPs/polyvinyl alcohol (PVA) nanofibrous membranes were fabricated by electrospinning with different zinc acetate concentrations. Characterization results indicated that, with 5 mM zinc acetate, uniform size ZnO NPs (~40 nm) were formed and evenly distributed on the membrane surface. The surfaces became more hydrophobic with higher concentration of zinc acetate. ZnO NPs/PVA nanofibrous membranes showed a broad spectrum of antimicrobial activities and cell adhesion inhibiting effects against four microorganisms including Gram-positive Staphylococcus aureus, Gram-negative Escherichia coli, fungi Candida albicans, and spores of Aspergillus niger. Our data revealed that the major antimicrobial mechanism could be attributed to cell membrane damage and cellular internalization of ZnO NPs, while the hydrophobic surface of the membrane primarily contributed to the cell adhesion inhibition. This study suggests that ZnO NPs/PVA nanofibrous membranes could potentially be used as an effective antimicrobial agent to maintain agricultural and food safety.
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DOI：
10.1590/s1517-83822008000100003
发表时间：
2008-01
期刊：
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
影响因子：
--
作者：
Hamadi F;Latrache H;Zahir H;Elghmari A;Timinouni M;Ellouali M
通讯作者：
Ellouali M
DOI：
10.1016/j.nano.2010.10.001
发表时间：
2011-04-01
影响因子：
5.4
作者：
Premanathan, Mariappan;Karthikeyan, Krishnamoorthy;Manivannan, Govindasamy
通讯作者：
Manivannan, Govindasamy
影响因子：
16.6
作者：
Acatay, K;Simsek, E;Menceloglu, YZ
通讯作者：
Menceloglu, YZ
影响因子：
3.9
作者：
P. Aurang;O. Demircioglu;F. Es;R. Turan;H. Unalan
通讯作者：
P. Aurang;O. Demircioglu;F. Es;R. Turan;H. Unalan
影响因子：
3.5
作者：
Krishnamoorthy, Karthikeyan;Premanathan, Mariappan;Kim, Sang Jae
通讯作者：
Kim, Sang Jae