Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats: focus on ghrelin and nesfatin-1.
Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats: focus on ghrelin and nesfatin-1.
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DOI：
10.1113/expphysiol.2013.074930
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发表时间：
2013-12
影响因子：
2.7
通讯作者：
Mulholland MW
中科院分区：
文献类型：
--
作者：
Zhang W;Zhang C;Fritze D;Chai B;Li J;Mulholland MW
Previous studies demonstrate that mTOR signaling in the hypothalamus is involved in the control of energy homeostasis. The aim of this study is to characterize the effect of mTOR signaling in the dorsal motor nucleus of vagus (DMNV) on the energy intake. Phosphor-mTOR was detected in the DMNV neurons and its levels increased by energy deprivation. Rapamycin significantly inhibited mTOR activity and reduced food intake when administrated into 4th ventricle. Exposure of DMNV neurons to ghrelin increased the phosphorylation of mTOR. Fourth ventricle injection of ghrelin significantly increased food intake relative to the control vehicle. Pre-treatment with rapamycin for 15 min attenuated the orexigenic effect of ghrelin. Reduction in the phosphorylation of mTOR was observed following 4th intracerebroventricular injection of nesfatin-1. When administrated by 4th ICV injection, nesfatin-1 suppressed the food intake as compared with the control. The anorexigenic effect of nesfatin-1 was significantly attenuated by pre-treatment with leucine for 15 min. All these studies suggest that mTOR signaling in the DMNV neurons regulates both the nutrient and hormonal signals for the modulation of food intake.
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影响因子：
3.5
作者：
Browning KN;Travagli RA
通讯作者：
Travagli RA
影响因子：
29
作者：
Blouet C;Schwartz GJ
通讯作者：
Schwartz GJ
影响因子：
56.9
作者：
Cota, D;Proulx, K;Seeley, RJ
通讯作者：
Seeley, RJ
mTOR 依赖性胃 Nesfatin-1/NUCB2 调节
影响因子：
--
作者：
Li, Ziru;Xu, Geyang;Zhang, Weizhen
通讯作者：
Zhang, Weizhen
影响因子：
56.9
作者：
Dennis, PB;Jaeschke, A;Thomas, G
通讯作者：
Thomas, G